m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02999)
Name
2-Methyl-2,4-Pentanediol
Synonyms
2-METHYL-2,4-PENTANEDIOL; 107-41-5; 2-Methylpentane-2,4-diol; Pinakon; 2,4-Dihydroxy-2-methylpentane; 2,4-Pentanediol, 2-methyl-; Diolane; Isol; 4-Methyl-2,4-pentanediol; 1,1,3-Trimethyltrimethylenediol; 2-Methyl pentane-2,4-diol; 2-Methyl-2,4-pentandiol; Caswell No. 574; alpha,alpha,alpha'-Trimethyltrimethylene glycol; 1,3-dimethyl-3-hydroxybutanol; Hexylene glycol [NF]; HSDB 1126; 1,3,3-trimethyl-1,3-propanediol; (+-)-2-Methyl-2,4-pentanediol; NSC 8098; EINECS 203-489-0; EPA Pesticide Chemical Code 068601; BRN
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Status
Investigative
Structure
Formula
C6H14O2
InChI
1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3
InChIKey
SVTBMSDMJJWYQN-UHFFFAOYSA-N
PubChem CID
7870
TTD Drug ID
D06GOK
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Heat shock protein 90 alpha (HSP90A)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [1], [2]
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heat shock protein 90 alpha (HSP90A) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Heat shock protein 90 alpha (HSP90A). [2], [3]
Nitric oxide synthase endothelial (NOS3)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Nitric oxide synthase endothelial (NOS3) is a therapeutic target for 2-Methyl-2,4-Pentanediol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Methyl-2,4-Pentanediol through regulating the expression of Nitric oxide synthase endothelial (NOS3). [4], [5]
References
Ref 1 m6A RNA Methylation Controls Proliferation of Human Glioma Cells by Influencing Cell Apoptosis. Cytogenet Genome Res. 2019;159(3):119-125. doi: 10.1159/000499062. Epub 2019 Oct 23.
Ref 2 Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. doi: 10.2174/187152008785914824.
Ref 3 Modification of N6-methyladenosine RNA methylation on heat shock protein expression. PLoS One. 2018 Jun 14;13(6):e0198604. doi: 10.1371/journal.pone.0198604. eCollection 2018.
Ref 4 N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. doi: 10.1161/ATVBAHA.121.317295. Epub 2022 Mar 17.
Ref 5 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. doi: 10.1021/jm950766n.