m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02996)
Name
Hydrogen peroxide
Synonyms
Hydrogen dioxide; Hydrogen dioxide solution; Hydrogen peroxide (H2O2); Hydrogen peroxide solution; Hydrogen peroxide, 30%; Hydrogen peroxide, 90%; Hydrogen peroxide, solution; Inhibine; Interox; Kastone; Lensept; Perone; Perone 30; Perone 35; Albone; Dihydrogen dioxide; Elawox; Hioxyl; Perone 50; Peroxaan; Peroxan; Peroxide; Superoxol; T-Stuff; Wasserstoffperoxid; Waterstofperoxyde; hydrogen peroxide; hydroperoxide; oxydol; perhydrol; 7722-84-1; Albone 35; Albone 35CG; Albone 50; Albone 50CG; Albone 70; Albone 70CG; Albone DS; H2O2
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Status
Approved
Structure
Formula
H2O2
InChI
1S/H2O2.O.U/c1-2;;/h1-2H;;/q;-2;
InChIKey
MHAJPDPJQMAIIY-UHFFFAOYSA-N
PubChem CID
784
INTEDE Drug ID
DR0832
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Hydrogen peroxide. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Hydrogen peroxide through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Hydrogen peroxide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydrogen peroxide through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol. 2000 Sep;74(1-2):11-8. doi: 10.1016/s0960-0760(00)00083-2.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.