m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02987)
Name
Heparin
Synonyms
Heparin [BAN]; Heparina; Heparine; Heparinum; Hepathrom; Lipo-hepin; Liquaemin; Liquemin; Lovenox; Lovenox HP; Low molecular weight heparin; Multiparin; Nadroparin; Nadroparine; Normiflo; Novoheparin; Octaparin; PK-10169; Pabyrin; Parnaparin; Adomiparin; Ardeparin; Bemiparin; Clexane; Clivarin; Depo-Heparin; Eparina [DCIT]; Fluxum; Fragmin A; Fragmin B; Hed-heparin; Parvoparin; Pularin; Reviparin; SEMULOPARIN; Sandoparin; Subeparin; Sublingula; Tinzaparin; Triofiban; Vetren; Vitrum AB; enoxaparin; heparin; 9005-49-6; CY 216; FR 860; LMWH
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Status
Approved
Structure
3D MOL
2D MOL
Formula
C26H42N2O37S5
InChI
1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
InChIKey
HTTJABKRGRZYRN-UHFFFAOYSA-N
PubChem CID
772
INTEDE Drug ID
DR0806
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Heparanase (HPSE)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Heparanase (HPSE) is a therapeutic target for Heparin. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of Heparin through regulating the expression of Heparanase (HPSE). [1], [2]
References
Ref 1 Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability. Bioengineered. 2021 Dec;12(2):11267-11276. doi: 10.1080/21655979.2021.2002495.
Ref 2 Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol. 2011 Dec;128(6):1310-1317.e8. doi: 10.1016/j.jaci.2011.04.011. Epub 2011 May 14.