m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02962)
Name
HBX19818
Synonyms
HBX 19818; 1426944-49-1; CHEMBL2398213; 9-Chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-2-acridinecarboxamide; N-(3-(benzyl(methyl)amino)propyl)-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide; N-[3-[benzyl(methyl)amino]propyl]-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide; SCHEMBL20007093; BDBM50436150; HBX-19818; NCGC00378705-01; HY-17540; J3.502.626F
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Status
Preclinical
Structure
Formula
C25H28ClN3O
InChI
1S/C25H28ClN3O/c1-29(17-18-8-3-2-4-9-18)15-7-14-27-25(30)19-12-13-23-21(16-19)24(26)20-10-5-6-11-22(20)28-23/h2-4,8-9,12-13,16H,5-7,10-11,14-15,17H2,1H3,(H,27,30)
InChIKey
ZCALMLVWZSQGGR-UHFFFAOYSA-N
PubChem CID
73349008
TTD Drug ID
DA0OZ2
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Herpesvirus ubiquitin-specific protease (HAUSP)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for HBX19818. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of HBX19818 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Herpesvirus ubiquitin-specific protease (HAUSP) is a therapeutic target for HBX19818. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HBX19818 through regulating the expression of Herpesvirus ubiquitin-specific protease (HAUSP). [2], [3]
References
Ref 1 The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA. Biochem Biophys Res Commun. 2019 May 7;512(3):479-485. doi: 10.1016/j.bbrc.2019.03.093. Epub 2019 Mar 21.
Ref 2 P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging (Albany NY). 2020 Jun 9;12(11):10969-10982. doi: 10.18632/aging.103309. Epub 2020 Jun 9.
Ref 3 Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7. J Oncol. 2022 May 5;2022:6167832. doi: 10.1155/2022/6167832. eCollection 2022.