m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02797)
Name |
Taurocholic acid
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Synonyms |
2-((3-alpha,7-alpha,12-alpha-Trihydroxy-24-oxo-5-be ta-cholan-24-yl)amino)ethanesulfonic acid; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 24-taurine; 81-24-3; Acidum cholatauricum; C26H45NO7S; Cholaic acid; Cholic acid taurine conjugate; Cholyltaurine; EINECS 201-336-2; Ethanesulfonic acid, 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-; HSDB 832; N-Choloyltaurine; NSC 25505; NSC25505; TAUROCHOLIC ACID; Taurine Cholate; Taurine, N-choloyl-; Taurocholate; Taurocholic acid; UNII-5E090O0G3Z; [3H]taurocholic acid
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Status |
Terminated
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Structure |
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Formula |
C26H45NO7S
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InChI |
1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
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InChIKey |
WBWWGRHZICKQGZ-HZAMXZRMSA-N
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PubChem CID | |||||
VARIDT Drug ID |
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Breast cancer resistance protein (ABCG2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Breast cancer resistance protein (ABCG2) is a therapeutic target for Taurocholic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Taurocholic acid through regulating the expression of Breast cancer resistance protein (ABCG2). | [1], [2] | ||
References