m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02693)
Name
ASN-11124542
Synonyms
AC1O5VPR; ASN 11124542
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Status
Investigative
Structure
Formula
C13H8N4OS
InChI
1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChIKey
VFBGXTUGODTSPK-BAQGIRSFSA-N
PubChem CID
6490494
TTD Drug ID
D0C1DQ
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Tyrosine-protein kinase EIF2AK2 (p68)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Tyrosine-protein kinase EIF2AK2 (p68) is a therapeutic target for ASN-11124542. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of ASN-11124542 through regulating the expression of Tyrosine-protein kinase EIF2AK2 (p68). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Tyrosine-protein kinase EIF2AK2 (p68) is a therapeutic target for ASN-11124542. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of ASN-11124542 through regulating the expression of Tyrosine-protein kinase EIF2AK2 (p68). [1], [2]
References
Ref 1 N(6)-Methyladenosines Modulate A-to-I RNA Editing. Mol Cell. 2018 Jan 4;69(1):126-135.e6. doi: 10.1016/j.molcel.2017.12.006.
Ref 2 Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. doi: 10.1016/j.bmcl.2011.04.149. Epub 2011 May 13.