m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02634)
Name
All-trans-retinal
Synonyms
E-Retinal; RR725D715M; Retinal, all-trans-; Retinaldehyde (VAN); Retinene 1; Retinyl aldehyde; TOCOPHEROL, ALPHA; Vitamin A1 aldehyde; all-E-Retinal; all-trans-Retinal; all-trans-Retinaldehyde; all-trans-Retinene; all-trans-Vitamin A aldehyde; axerophthal; retinal; retinaldehyde; retinene; trans-Retinal; trans-Vitamin A aldehyde; vitamin A aldehyde; .alpha.-Retinene; 116-31-4; BRN 1914183; CHEBI:17898; EINECS 204-135-8; MFCD00001550; NCYCYZXNIZJOKI-OVSJKPMPSA-N; NSC 122757; NSC 626581; NSC626581; UNII-RR725D715M
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Status
Investigative
Structure
Formula
C20H28O
InChI
1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChIKey
NCYCYZXNIZJOKI-OVSJKPMPSA-N
PubChem CID
638015
INTEDE Drug ID
DR2032
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Aldehyde dehydrogenase 1 (ALDH1)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Aldehyde dehydrogenase 1 (ALDH1) is a therapeutic target for All-trans-retinal. The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) has potential in affecting the response of All-trans-retinal through regulating the expression of Aldehyde dehydrogenase 1 (ALDH1). [1], [2]
References
Ref 1 RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1. Leukemia. 2020 May;34(5):1354-1363. doi: 10.1038/s41375-019-0656-9. Epub 2019 Nov 25.
Ref 2 Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact. 2013 Feb 25;202(1-3):78-84. doi: 10.1016/j.cbi.2012.11.019. Epub 2012 Dec 7.