m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02612)
Name
Methionine
Synonyms
Acimethin; Cymethion; L-(-)-Methionine; L-Homocysteine, S-methyl-; L-Methionin; L-Methioninum; L-methionine; Liquimeth; METHIONINE, L-; Methilanin; Methionine (VAN); Methioninum; Methioninum [INN-Latin]; Metionina [DCIT]; Neo-methidin; Poly-L-methionine; Polymethionine; S-Methionine; methionine; metionina; (2S)-2-amino-4-(methylsulfanyl)butanoic acid; (L)-Methionine; (S)-2-Amino-4-(methylthio)butanoic acid; (S)-methionine; 63-68-3; L-alpha-Amino-gamma-methylmercaptobutyric acid; h-Met-h; h-Met-oh
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Status
Investigative
Structure
Formula
C5H11NO2S
InChI
1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKey
FFEARJCKVFRZRR-BYPYZUCNSA-N
PubChem CID
6137
INTEDE Drug ID
DR1043
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
S-adenosylmethionine synthase 2 (MAT2A)
Methyltransferase-like 16 (METTL16)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary S-adenosylmethionine synthase 2 (MAT2A) is a therapeutic target for Methionine. The Methyltransferase-like 16 (METTL16) has potential in affecting the response of Methionine through regulating the expression of S-adenosylmethionine synthase 2 (MAT2A). [1], [2]
References
Ref 1 Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017 Nov;18(11):2004-2014. doi: 10.15252/embr.201744940. Epub 2017 Oct 19.
Ref 2 Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. doi: 10.1053/j.gastro.2007.03.114. Epub 2007 Apr 11.