m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02582)
Name
Uridine
Synonyms
Uracil riboside; Uracil, 1-beta-D-ribofuranosyl-; DRTQHJPVMGBUCF-XVFCMESISA-N; Uracil-1-beta-d-ribofuranoside; Uridin; WHI7HQ7H85; b-Uridine; beta-Uridine; d-uridine; uridine; uridine-1'-13C; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-.beta.-D-Ribofuranosyluracil; 1-beta-D-Ribofuranosyluracil; 58-96-8; AI3-52690; C9H12N2O6; CHEBI:16704; EINECS 200-407-5; MFCD00006526; MLS000069625; NSC 20256; SMR000058222; UNII-WHI7HQ7H85; Urd
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Status
Approved
Structure
Formula
C9H12N2O6
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKey
DRTQHJPVMGBUCF-XVFCMESISA-N
PubChem CID
6029
INTEDE Drug ID
DR2135
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Uridine-cytidine kinase 2 (UCK2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Uridine-cytidine kinase 2 (UCK2) is a therapeutic target for Uridine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Uridine through regulating the expression of Uridine-cytidine kinase 2 (UCK2). [1], [2]
References
Ref 1 METTL3-induced UCK2 m(6)A hypermethylation promotes melanoma cancer cell metastasis via the WNT/Beta-catenin pathway. Ann Transl Med. 2021 Jul;9(14):1155. doi: 10.21037/atm-21-2906.
Ref 2 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. doi: 10.1124/mol.59.5.1181.