m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02568)
Name
Sucrose
Synonyms
57-50-1; Amerfand; Amerfond; Beet sugar; CCRIS 2120; CHEBI:17992; Cane sugar; Confectioner's sugar; D(+)-Saccharose; D(+)-Sucrose; D-(+)-Saccharose; D-Saccharose; D-Sucrose; Granulated sugar; HSDB 500; Microse; Rock candy; Rohrzucker; Saccharose; Saccharum; Sacharose; Sucraloxum [INN-Latin]; Sucrose [USAN:JAN]; Sucrose, dust; Sucrose, pure; Table sugar; White sugar; alpha-D-Glucopyranosyl beta-D-fructofuranoside; beta-D-Fructofuranosyl alpha-D-glucopyranoside; beta-D-Fructofuranosyl-alpha-D-glucopyranoside; sacarosa; sugar
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Status
Phase 4
Structure
Formula
C12H22O11
InChI
1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
InChIKey
CZMRCDWAGMRECN-UGDNZRGBSA-N
PubChem CID
5988
VARIDT Drug ID
DR00131
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Solute carrier family 45 member 4 (SLC45A4)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Solute carrier family 45 member 4 (SLC45A4) is a therapeutic target for Sucrose. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Sucrose through regulating the expression of Solute carrier family 45 member 4 (SLC45A4). [1], [2]
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Solute carrier family 45 member 4 (SLC45A4) is a therapeutic target for Sucrose. The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of Sucrose through regulating the expression of Solute carrier family 45 member 4 (SLC45A4). [1], [2]
References
Ref 1 Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs. Cell Rep. 2017 Aug 29;20(9):2262-2276. doi: 10.1016/j.celrep.2017.08.027.
Ref 2 The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60. doi: 10.1016/j.mam.2012.05.014.