m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02404)
Name
5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione
Synonyms
CHEMBL176517; 219311-20-3; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(4-phenoxyphenyl)-; SCHEMBL6380971; CTK0J6997; DTXSID60470422; NNRYJLARUIVRRO-UHFFFAOYSA-N; 5-(4'-phenoxyphenyl)barbituric acid; 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
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Status
Investigative
Structure
Formula
C16H12N2O4
InChI
1S/C16H12N2O4/c19-14-13(15(20)18-16(21)17-14)10-6-8-12(9-7-10)22-11-4-2-1-3-5-11/h1-9H,(H3,17,18,19,20,21)
InChIKey
CVMFBMDAPZFQBR-UHFFFAOYSA-N
PubChem CID
53742316
TTD Drug ID
D07LTB
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Matrix metalloproteinase-2 (MMP-2)
E3 ubiquitin-protein ligase Hakai (CBLL1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The E3 ubiquitin-protein ligase Hakai (CBLL1) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [2], [3]
Matrix metalloproteinase-9 (MMP-9)
E3 ubiquitin-protein ligase Hakai (CBLL1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The E3 ubiquitin-protein ligase Hakai (CBLL1) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [1], [4]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [4], [5]
References
Ref 1 CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion. Thorac Cancer. 2019 Jun;10(6):1479-1488. doi: 10.1111/1759-7714.13097. Epub 2019 May 23.
Ref 2 A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics simulations. J Med Chem. 2004 Jun 3;47(12):3065-74. doi: 10.1021/jm030570k.
Ref 3 RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2. Melanoma Res. 2019 Aug;29(4):382-389. doi: 10.1097/CMR.0000000000000580.
Ref 4 Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. doi: 10.1016/s0960-894x(01)00104-4.
Ref 5 The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biol Toxicol. 2022 Feb;38(1):167-183. doi: 10.1007/s10565-021-09585-1. Epub 2021 Mar 4.