m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02251)
Name |
3,7,3',4'-TETRAHYDROXYFLAVONE
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Synonyms |
Fisetin; 528-48-3; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 5-Desoxyquercetin; Fustel; Cotinin; Viset; 3,3',4',7-Tetrahydroxyflavone; Fisetholz; Superfustel; Fustet; Fietin; Junger fustik; 3,7,3',4'-Tetrahydroxyflavone; Ventin sumach; Zante fustic; Young fustic; Superfustel K; Ungarisches gelbholz; CI Natural Brown 1; Young fustic crystals; Bois bleu de Honqrie; BOIS bleude honqrie; CI 75620; NSC 407010; NSC 656275; 5-Deoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; Natural Brown 1; FISETIN
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Status |
Investigative
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Structure |
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Formula |
C15H10O6
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InChI |
1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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InChIKey |
XHEFDIBZLJXQHF-UHFFFAOYSA-N
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PubChem CID | |||||
TTD Drug ID |
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cyclin-dependent kinase 6 (CDK6)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cyclin-dependent kinase 6 (CDK6) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Cyclin-dependent kinase 6 (CDK6). | [1], [2] | ||
Fatty acid synthase (FASN)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Fatty acid synthase (FASN) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Fatty acid synthase (FASN). | [3], [4] | ||
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Fatty acid synthase (FASN) is a therapeutic target for 3,7,3',4'-TETRAHYDROXYFLAVONE. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3,7,3',4'-TETRAHYDROXYFLAVONE through regulating the expression of Fatty acid synthase (FASN). | [4], [5] | ||
References