m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02152)
Name
Procarbazine
Synonyms
Procarbazin; Procarbazin [German]; Procarbazina; Procarbazina [INN-Spanish]; Procarbazine [INN:BAN]; Procarbazinum; Procarbazinum [INN-Latin]; Ibenzmethyzine; Natulan; Ro 4-6467; procarbazine; 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; 671-16-9; Ibenzmethyzin; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide; p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide
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Status
Approved
Structure
Formula
C12H19N3O
InChI
1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
InChIKey
CPTBDICYNRMXFX-UHFFFAOYSA-N
PubChem CID
4915
INTEDE Drug ID
DR1344
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Procarbazine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Procarbazine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Procarbazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Procarbazine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 Tumour cytochrome P450 and drug activation. Curr Pharm Des. 2002;8(15):1335-47. doi: 10.2174/1381612023394502.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.