General Information of the Drug (ID: M6APDG02126)
Name
N-oxo-2-(phenylsulfonylamino)ethanamide
Synonyms
N-oxo-2-(phenylsulfonylamino)ethanamide; SCHEMBL20553203; 2-benzenesulfonamido-N-oxoacetamide; DB07922; N-oxo-N~2~-(phenylsulfonyl)glycinamide
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Status
Investigative
Structure
Formula
C8H8N2O4S
InChI
1S/C8H8N2O4S/c11-8(10-12)6-9-15(13,14)7-4-2-1-3-5-7/h1-5,9H,6H2
InChIKey
LBEMJFIVKDOIBO-UHFFFAOYSA-N
PubChem CID
46937108
TTD Drug ID
D0W9TD
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Matrix metalloproteinase-12 (MMP-12)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for N-oxo-2-(phenylsulfonylamino)ethanamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-oxo-2-(phenylsulfonylamino)ethanamide through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [1], [2]
References
Ref 1 The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biol Toxicol. 2022 Feb;38(1):167-183. doi: 10.1007/s10565-021-09585-1. Epub 2021 Mar 4.
Ref 2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. doi: 10.1093/nar/28.1.235.