m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02089)
Name
N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide
Synonyms
CHEMBL1091737; N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide
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Status
Investigative
Structure
Formula
C23H17FN2O
InChI
1S/C23H17FN2O/c24-21-9-5-17(6-10-21)16-26(22-11-13-25-14-12-22)23(27)20-8-7-18-3-1-2-4-19(18)15-20/h1-15H,16H2
InChIKey
MQJXOIDGELXEHE-UHFFFAOYSA-N
PubChem CID
46886448
TTD Drug ID
D07TTR
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Stress-activated protein kinase 2a (p38 alpha)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Stress-activated protein kinase 2a (p38 alpha) is a therapeutic target for N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide through regulating the expression of Stress-activated protein kinase 2a (p38 alpha). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Stress-activated protein kinase 2a (p38 alpha) is a therapeutic target for N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide through regulating the expression of Stress-activated protein kinase 2a (p38 alpha). [2], [3]
YTH domain-containing family protein 3 (YTHDF3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Stress-activated protein kinase 2a (p38 alpha) is a therapeutic target for N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide. The YTH domain-containing family protein 3 (YTHDF3) has potential in affecting the response of N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide through regulating the expression of Stress-activated protein kinase 2a (p38 alpha). [1], [2]
References
Ref 1 N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-KappaB pathways. Bioengineered. 2022 May;13(5):11973-11986. doi: 10.1080/21655979.2021.1999550.
Ref 2 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095.
Ref 3 m(6)A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. Onco Targets Ther. 2019 Jun 4;12:4391-4402. doi: 10.2147/OTT.S201052. eCollection 2019.