m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02003)
| Name |
Ofloxacin
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| Synonyms |
(+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (+/-)-Floxin; (-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure; 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; Bactocin; DEXTROFLOXACINE; DL 8280; DL-8280; DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin; Danoflox; Effexin; Exocin; Exocine; FLOXIN IN DEXTROSE 5%; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Flobacin; Flodemex; Flotavid; Flovid; Floxal; Floxil; Floxin; Floxin (TN); Floxin Otic (TN); Floxin otic; Floxstat; Fugacin; HOE 280; HOE-280;Hoe-280; Inoflox; Kinflocin; Kinoxacin; Liflox; Loxinter; Marfloxacin; Marfloxacin (TN); Medofloxine; Mergexin; Novecin; Nufafloqo; O 8757; O-Flox; OFLX; OFX; ORF 18489; ORF-28489; Obide; Occidal; Ocuflox; Ocuflox (TN); Ofcin; Oflin; Oflocee; Oflocet; Oflocin; Oflodal; Oflodex; Oflodura; Oflox; Ofloxacin (JP15/USP/INN); Ofloxacin Otic; Ofloxacin [USAN:BAN:INN:JAN]; Ofloxacin, (S)-Isomer; Ofloxacina; Ofloxacina [DCIT]; Ofloxacine; Ofloxacine [French]; Ofloxacino; Ofloxacino [Spanish]; Ofloxacinum; Ofloxacinum [Latin]; Ofloxin; Ofus; Onexacin; Operan; Orocin; Otonil; Oxaldin; PT 01; Pharflox; Praxin; Puiritol; Qinolon; Qipro; Quinolon; Quotavil; Rilox; Ru-43280; Sinflo; Tabrin; Taravid; Tariflox; Tarivid; Telbit; Tructum; Uro Tarivid; Viotisone; Visiren; WP-0405; XED; Zanocin
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| Status |
Approved
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| Structure |
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| Formula |
C18H20FN3O4
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| InChI |
1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
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| InChIKey |
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
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| PubChem CID | |||||
| VARIDT Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Breast cancer resistance protein (ABCG2)
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Breast cancer resistance protein (ABCG2) is a therapeutic target for Ofloxacin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ofloxacin through regulating the expression of Breast cancer resistance protein (ABCG2). | [1], [2] | ||
References