m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01990)
Name
5-(biphenyl-4-yl)-3-methoxypentanoic acid
Synonyms
CHEMBL583771; 5-(biphenyl-4-yl)-3-methoxypentanoic acid
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Status
Investigative
Structure
Formula
C18H20O3
InChI
1S/C18H20O3/c1-21-17(13-18(19)20)12-9-14-7-10-16(11-8-14)15-5-3-2-4-6-15/h2-8,10-11,17H,9,12-13H2,1H3,(H,19,20)
InChIKey
KYPWLTXIHUQMGA-UHFFFAOYSA-N
PubChem CID
45482998
TTD Drug ID
D0TL3N
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Matrix metalloproteinase-12 (MMP-12)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 5-(biphenyl-4-yl)-3-methoxypentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(biphenyl-4-yl)-3-methoxypentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [1], [2]
References
Ref 1 The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biol Toxicol. 2022 Feb;38(1):167-183. doi: 10.1007/s10565-021-09585-1. Epub 2021 Mar 4.
Ref 2 The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. doi: 10.1016/j.bmcl.2009.07.155. Epub 2009 Aug 6.