m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01893)
Name
PD-068235
Synonyms
CHEMBL455856; PD-068235; BDBM50266362; PD-068253
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Status
Investigative
Structure
Formula
C11H15N3O3S
InChI
1S/C11H15N3O3S/c1-5-6-13-7-8(14(16)17)18-10(13)12-9(15)11(2,3)4/h5,7H,1,6H2,2-4H3
InChIKey
SPVZIILAYYBEDM-UHFFFAOYSA-N
PubChem CID
44581800
TTD Drug ID
D0X9UJ
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for PD-068235. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of PD-068235 through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [1], [2]
References
Ref 1 The m(6)A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG. Acta Pharmacol Sin. 2022 May;43(5):1311-1323. doi: 10.1038/s41401-021-00756-8. Epub 2021 Aug 30.
Ref 2 Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. doi: 10.1016/j.ejmech.2008.01.032. Epub 2008 Feb 3.