m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01762)
Name
PLSQETFSDLWKLLPEN-NH2
Synonyms
CHEMBL267823
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Status
Investigative
Structure
3D MOL
2D MOL
Formula
C93H142N22O28
InChI
1S/C93H142N22O28/c1-46(2)35-61(83(133)108-65(40-52-43-99-54-22-14-13-21-53(52)54)87(137)100-56(23-15-16-32-94)79(129)106-62(36-47(3)4)84(134)111-67(38-49(7)8)93(143)115-34-18-25-70(115)91(141)103-58(27-30-73(121)122)81(131)104-60(77(97)127)41-72(96)120)107-88(138)66(42-75(125)126)109-90(140)69(45-117)113-86(136)64(39-51-19-11-10-12-20-51)110-92(142)76(50(9)118)114-82(132)59(28-31-74(123)124)101-80(130)57(26-29-71(95)119)102-89(139)68(44-116)112-85(135)63(37-48(5)6)105-78(128)55-24-17-33-98-55/h10-14,19-22,43,46-50,55-70,76,98-99,116-118H,15-18,23-42,44-45,94H2,1-9H3,(H2,95,119)(H2,96,120)(H2,97,127)(H,100,137)(H,101,130)(H,102,139)(H,103,141)(H,104,131)(H,105,128)(H,106,129)(H,107,138)(H,108,133)(H,109,140)(H,110,142)(H,111,134)(H,112,135)(H,113,136)(H,114,132)(H,121,122)(H,123,124)(H,125,126)/t50-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1
InChIKey
JGQYEMDYGMNCJX-RDLTZJDDSA-N
PubChem CID
44412124
TTD Drug ID
D08YAF
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Ubiquitin-protein ligase E3 Mdm2 (MDM2)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Ubiquitin-protein ligase E3 Mdm2 (MDM2) is a therapeutic target for PLSQETFSDLWKLLPEN-NH2. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of PLSQETFSDLWKLLPEN-NH2 through regulating the expression of Ubiquitin-protein ligase E3 Mdm2 (MDM2). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Ubiquitin-protein ligase E3 Mdm2 (MDM2) is a therapeutic target for PLSQETFSDLWKLLPEN-NH2. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of PLSQETFSDLWKLLPEN-NH2 through regulating the expression of Ubiquitin-protein ligase E3 Mdm2 (MDM2). [1], [2]
References
Ref 1 The m(6)A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia. J Cancer. 2022 Jan 4;13(3):1019-1030. doi: 10.7150/jca.60381. eCollection 2022.
Ref 2 Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62. doi: 10.1021/jm060023+.