m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01692)
Name
6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine
Synonyms
SCHEMBL6660879
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Status
Investigative
Structure
Formula
C13H9FN4
InChI
1S/C13H9FN4/c14-10-4-1-9(2-5-10)3-6-11-12-13(17-7-15-11)18-8-16-12/h1-8H,(H,15,16,17,18)/b6-3+
InChIKey
QUTNZZOCHSVJRB-ZZXKWVIFSA-N
PubChem CID
44387948
TTD Drug ID
D02TYK
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Extracellular signal-regulated kinase 1 (ERK1)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Extracellular signal-regulated kinase 1 (ERK1) is a therapeutic target for 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine through regulating the expression of Extracellular signal-regulated kinase 1 (ERK1). [1], [2]
YTH domain-containing family protein 3 (YTHDF3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Extracellular signal-regulated kinase 1 (ERK1) is a therapeutic target for 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine. The YTH domain-containing family protein 3 (YTHDF3) has potential in affecting the response of 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine through regulating the expression of Extracellular signal-regulated kinase 1 (ERK1). [1], [2]
References
Ref 1 N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-KappaB pathways. Bioengineered. 2022 May;13(5):11973-11986. doi: 10.1080/21655979.2021.1999550.
Ref 2 Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26. doi: 10.1159/000341469. Epub 2012 Sep 12.