m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01620)
Name
KH-CB19
Synonyms
KH CB19
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Status
Investigative
Structure
Formula
C15H13Cl2N3O2
InChI
1S/C15H13Cl2N3O2/c1-3-22-15(21)14-11(8(6-18)7-19)9-4-5-10(16)12(17)13(9)20(14)2/h4-6H,3,18H2,1-2H3/b8-6-
InChIKey
CXJCGSPAPOTTSF-VURMDHGXSA-N
PubChem CID
44237094
TTD Drug ID
D00BAJ
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for KH-CB19. The Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) has potential in affecting the response of KH-CB19 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for KH-CB19. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of KH-CB19 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target for KH-CB19. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of KH-CB19 through regulating the expression of Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A). [1], [2]
References
Ref 1 N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015 Feb 26;518(7540):560-4. doi: 10.1038/nature14234.
Ref 2 Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26.