General Information of the Drug (ID: M6APDG01208)
Name
N7-hydroxy-N1-phenyl-2-propoxyheptanediamide
Synonyms
CHEMBL251406; N7-hydroxy-N1-phenyl-2-propoxyheptanediamide; SCHEMBL8144856
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Status
Investigative
Structure
Formula
C16H24N2O4
InChI
1S/C16H24N2O4/c1-2-12-22-14(10-6-7-11-15(19)18-21)16(20)17-13-8-4-3-5-9-13/h3-5,8-9,14,21H,2,6-7,10-12H2,1H3,(H,17,20)(H,18,19)
InChIKey
HYIYBZGKHUILKH-UHFFFAOYSA-N
PubChem CID
25065713
TTD Drug ID
D03TQD
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Histone deacetylase 2 (HDAC2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N7-hydroxy-N1-phenyl-2-propoxyheptanediamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N7-hydroxy-N1-phenyl-2-propoxyheptanediamide through regulating the expression of Histone deacetylase 2 (HDAC2). [1], [2]
References
Ref 1 The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. Int J Oncol. 2018 Feb;52(2):621-629. doi: 10.3892/ijo.2017.4219. Epub 2017 Dec 7.
Ref 2 Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. doi: 10.1016/j.bmcl.2007.09.014. Epub 2007 Sep 8.