m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01189)
Name
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole
Synonyms
CHEMBL452730; 5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole
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Status
Investigative
Structure
3D MOL
2D MOL
Formula
C17H15NOSe
InChI
1S/C17H15NOSe/c1-12-3-5-13(6-4-12)16-11-18-20-17(16)14-7-9-15(19-2)10-8-14/h3-11H,1-2H3
InChIKey
ZTXIFGCFDLCGKN-UHFFFAOYSA-N
PubChem CID
24884691
TTD Drug ID
D07RTV
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Prostaglandin G/H synthase 2 (COX-2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Prostaglandin G/H synthase 2 (COX-2) is a therapeutic target for 5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole through regulating the expression of Prostaglandin G/H synthase 2 (COX-2). [1], [2]
References
Ref 1 METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. Biochem Biophys Res Commun. 2019 Aug 13;516(1):22-27. doi: 10.1016/j.bbrc.2019.05.168. Epub 2019 Jun 8.
Ref 2 Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3014-8. doi: 10.1016/j.bmcl.2009.04.059. Epub 2009 Apr 20.