m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01081)
Name
HSDB-3466
Synonyms
BERGAPTAN; Bergapten; Bergaptene (DCF); Heraclin; Majudin; O-Methylbergaptol; Pentaderm; Psoraderm; bergaptene; 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 4-Methoxy-7H-furo[3,2-g]chromen-7-one; 4-Methoxyfuro[3,2-g]benzopyran-7-one; 4-methoxyfuro[3,2-g]chromen-7-one; 484-20-8; 5-Methoxy psoralen; 5-Methoxy-6,7-furanocoumarin; 5-Methoxyfuranocoumarin; 5-Methoxypsoralen; 5-Mop; 5-methoxypsoralene; 7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-; CCRIS 4348; HSDB 3466; NSC 95437; UNII-4FVK84C92X
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Status
Phase 3
Structure
Formula
C12H8O4
InChI
1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3
InChIKey
BGEBZHIAGXMEMV-UHFFFAOYSA-N
PubChem CID
2355
INTEDE Drug ID
DR1910
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for HSDB-3466. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of HSDB-3466 through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for HSDB-3466. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of HSDB-3466 through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. doi: 10.1371/journal.pone.0075494. eCollection 2013.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.