m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00956)
Name
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
Synonyms
1,2-DIBROMO-4-(1,2-DIBROMOETHYL)CYCLOHEXANE; 3322-93-8; Citex BCL 462; Saytex BCL 462; Cyclohexane, 1,2-dibromo-4-(1,2-dibromoethyl)-; 1-(1,2-Dibromoethyl)-3,4-dibromocyclohexane; Vinylcyclohexene tetrabromide; 1,2-DIBROMO-4-(1,2-DIBROMOETHYL)-CYCLOHEXANE; 4-(1,2-Dibromoethyl)-1,2-dibromocyclohexane; CCRIS 3743; HSDB 6146; EINECS 222-036-8; BRN 1927455; CHEMBL375107; AK-78933; C8H12Br4; TBECH; AC1L2COC; DSSTox_CID_4947; DSSTox_RID_77594; DSSTox_GSID_24947; MLS002454355; 3-05-00-00093 (Beilstein Handbook Reference); SCHEMBL332771
    Click to Show/Hide
Status
Investigative
Structure
Formula
C8H12Br4
InChI
1S/C8H12Br4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h5-8H,1-4H2
InChIKey
PQRRSJBLKOPVJV-UHFFFAOYSA-N
PubChem CID
18728
TTD Drug ID
D06BLF
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Androgen receptor (AR)
ETS-related transcription factor Elf-3 (ELF3)
In total 2 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Androgen receptor (AR) is a therapeutic target for 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane. The ETS-related transcription factor Elf-3 (ELF3) has potential in affecting the response of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane through regulating the expression of Androgen receptor (AR). [1], [2]
Androgen receptor (AR) is a therapeutic target for 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane. The ETS-related transcription factor Elf-3 (ELF3) has potential in affecting the response of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane through regulating the expression of Androgen receptor (AR). [1], [3]
References
Ref 1 ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene. 2014 Feb 13;33(7):862-71. doi: 10.1038/onc.2013.15. Epub 2013 Feb 25.
Ref 2 Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. doi: 10.1016/j.bmcl.2009.02.104. Epub 2009 Mar 3.
Ref 3 Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. doi: 10.1016/j.bmcl.2006.03.047. Epub 2006 Apr 5.