m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00905)
Name
2-methylisoquinoline-1,3,4-trione
Synonyms
2-methylisoquinoline-1,3,4(2H)-trione; 21640-33-5; 2-methyl-isoquinoline-1,3,4-trione; 2-methylisoquinoline-1,3,4-trione; 2-methyl-1,2,3,4-tetrahydroisoquinoline-1,3,4-trione; N-methylphthalonimide; AC1LVZDH; AC1Q3XNZ; 1,3,4(2H)-Isoquinolinetrione, 2-methyl-; CHEMBL381480; SCHEMBL13442852; Isoquinoline-1,3,4-trione 2a; CTK4E7387; BDBM10248; DTXSID90364926; MolPort-001-798-932; ZINC2030689; CS-D0370; FCH830488; STK368698; AKOS005444509; MCULE-7985115369; ACM21640335; 2-methyl-1,3,4(2H)-isoquinolinetrione; AK325966
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Status
Investigative
Structure
Formula
C10H7NO3
InChI
1S/C10H7NO3/c1-11-9(13)7-5-3-2-4-6(7)8(12)10(11)14/h2-5H,1H3
InChIKey
LSVJISCDJHIYOW-UHFFFAOYSA-N
PubChem CID
1714901
TTD Drug ID
D0FZ7W
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Caspase-3 (CASP3)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-methylisoquinoline-1,3,4-trione. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of 2-methylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Caspase-3 (CASP3) is a therapeutic target for 2-methylisoquinoline-1,3,4-trione. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-methylisoquinoline-1,3,4-trione through regulating the expression of Caspase-3 (CASP3). [2], [3]
References
Ref 1 METTL14 Overexpression Promotes Osteosarcoma Cell Apoptosis and Slows Tumor Progression via Caspase 3 Activation. Cancer Manag Res. 2020 Dec 11;12:12759-12767. doi: 10.2147/CMAR.S284273. eCollection 2020.
Ref 2 Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. doi: 10.1016/j.bmc.2009.06.069. Epub 2009 Jul 7.
Ref 3 METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells. Open Med (Wars). 2019 Mar 2;14:25-31. doi: 10.1515/med-2019-0005. eCollection 2019.