m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00859)
Name
Alicaforsen
Synonyms
Alicaforsen [INN]; ISIS 2302; ISIS-2302; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)
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Status
Phase 3
Structure
3D MOL
2D MOL
PubChem CID
16197725
TTD Drug ID
D0P9BT
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Intercellular adhesion molecule ICAM-1 (ICAM1)
Fat mass and obesity-associated protein (FTO)
In total 2 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [1], [2]
Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [1], [3]
Methyltransferase-like 3 (METTL3)
In total 2 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [2], [4]
Intercellular adhesion molecule ICAM-1 (ICAM1) is a therapeutic target for Alicaforsen. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Alicaforsen through regulating the expression of Intercellular adhesion molecule ICAM-1 (ICAM1). [3], [4]
References
Ref 1 N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. doi: 10.1161/ATVBAHA.121.317295. Epub 2022 Mar 17.
Ref 2 US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
Ref 3 Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem. 1991 Sep 25;266(27):18162-71.
Ref 4 N(6)-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. Mol Ther Nucleic Acids. 2020 Jun 5;20:111-116. doi: 10.1016/j.omtn.2020.02.002. Epub 2020 Feb 11.