m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00826)
Name
N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide
Synonyms
CHEMBL538710; SCHEMBL3292721; SCHEMBL3292715; BDBM50293355
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Status
Investigative
Structure
Formula
C16H12N2O2
InChI
1S/C16H12N2O2/c17-11-13-3-8-15(9-4-13)14-6-1-12(2-7-14)5-10-16(19)18-20/h1-10,20H,(H,18,19)/b10-5+
InChIKey
NJUOLWKIAIFTKT-BJMVGYQFSA-N
PubChem CID
15986510
TTD Drug ID
D0W9BH
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Histone deacetylase 2 (HDAC2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Histone deacetylase 2 (HDAC2) is a therapeutic target for N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide through regulating the expression of Histone deacetylase 2 (HDAC2). [1], [2]
References
Ref 1 The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. Int J Oncol. 2018 Feb;52(2):621-629. doi: 10.3892/ijo.2017.4219. Epub 2017 Dec 7.
Ref 2 Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. doi: 10.1016/j.ejmech.2008.11.005. Epub 2008 Nov 19.