m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00809)
Name
2-Sulfhydryl-Ethanol
Synonyms
beta-Mercaptoethanol; 2-mercaptoethanol; 60-24-2; Thioglycol; Mercaptoethanol; Beta-Mercaptoethanol; Ethanol, 2-mercapto-; 2-Sulfanylethanol; 2-Thioethanol; Thioethylene glycol; 2-Hydroxyethanethiol; 2-Hydroxyethyl mercaptan; 2-Hydroxy-1-ethanethiol; Thiomonoglycol; Monothioglycol; 2-Mercapto-1-ethanol; 1-Ethanol-2-thiol; Hydroxyethyl mercaptan; Monothioethylene glycol; 2-Mercaptoethyl alcohol; 2-ME; Mercaptoetanol; Ethylene glycol, monothio-; 1-Hydroxy-2-mercaptoethane; 1-Mercapto-2-hydroxyethane; 2-Hydroxyethylmercaptan; Emery 5791; USAF EK-4196
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Status
Investigative
Structure
Formula
C2H6OS
InChI
1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
InChIKey
DGVVWUTYPXICAM-UHFFFAOYSA-N
PubChem CID
1567
TTD Drug ID
D0Q5FV
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
High mobility group protein B1 (HMGB1)
RNA demethylase ALKBH5 (ALKBH5)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary High mobility group protein B1 (HMGB1) is a therapeutic target for 2-Sulfhydryl-Ethanol. The RNA demethylase ALKBH5 (ALKBH5) has potential in affecting the response of 2-Sulfhydryl-Ethanol through regulating the expression of High mobility group protein B1 (HMGB1). [1], [2]
M-phase inducer phosphatase 2 (MPIP2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary M-phase inducer phosphatase 2 (MPIP2) is a therapeutic target for 2-Sulfhydryl-Ethanol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Sulfhydryl-Ethanol through regulating the expression of M-phase inducer phosphatase 2 (MPIP2). [3], [4]
References
Ref 1 ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response. Int J Radiat Oncol Biol Phys. 2021 Oct 1;111(2):491-501. doi: 10.1016/j.ijrobp.2021.05.115. Epub 2021 May 24.
Ref 2 Avontec Announces Results of a Multiple Dose Clinical Phase I Study with Its Drug Candidate AVT-02 UE Ointment After Topical Treatment in Male Healthy Volunteers. Avontec. 2008.
Ref 3 METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression. Exp Hematol Oncol. 2022 Mar 14;11(1):14. doi: 10.1186/s40164-022-00256-3.
Ref 4 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. doi: 10.1016/j.bmc.2008.08.009. Epub 2008 Aug 7.