m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00781)
Name
Disufenton
Synonyms
168021-77-0; UNII-797K01YF1M; 797K01YF1M; N-tert-butyl-1-(2,4-disulfophenyl)methanimine oxide; SCHEMBL727315; CHEMBL2111090; 2,4-disulfophenyl-N-t-butylnitrone; alpha-(2,4-disulfophenyl)-N-tert-butylnitrone; Q27266726
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Status
Phase 2
Structure
Formula
C11H15NO7S2
InChI
1S/C11H15NO7S2/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19)
InChIKey
OVTCHWSLKGENKP-UHFFFAOYSA-N
PubChem CID
151179
TTD Drug ID
D7M3JN
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Extracellular sulfatase Sulf-2 (SULF2)
Methyltransferase-like 16 (METTL16)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Extracellular sulfatase Sulf-2 (SULF2) is a therapeutic target for Disufenton. The Methyltransferase-like 16 (METTL16) has potential in affecting the response of Disufenton through regulating the expression of Extracellular sulfatase Sulf-2 (SULF2). [1], [2]
References
Ref 1 PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification. Environ Pollut. 2022 Jun 15;303:119115. doi: 10.1016/j.envpol.2022.119115. Epub 2022 Mar 5.
Ref 2 [KRP-297, MCC-555]. Nihon Rinsho. 2001 Nov;59(11):2200-6.