m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00778)
Name
2-Hexadecynoic acid
Synonyms
2-Hexadecynoic acid; hexadec-2-ynoic acid; 2834-03-9; 2-Hexadecynoate; N-2-Hexadecynoic acid; AC1L45K9; SCHEMBL2818253; CTK4G1266; DTXSID00182577; MECFGCCEVOFCNS-UHFFFAOYSA-N; NSC289580; LMFA01030494
    Click to Show/Hide
Status
Investigative
Structure
Formula
C16H28O2
InChI
1S/C16H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-13H2,1H3,(H,17,18)
InChIKey
MECFGCCEVOFCNS-UHFFFAOYSA-N
PubChem CID
151047
TTD Drug ID
D05HRK
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Fatty acid synthase (FASN)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 2-Hexadecynoic acid. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of 2-Hexadecynoic acid through regulating the expression of Fatty acid synthase (FASN). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Fatty acid synthase (FASN) is a therapeutic target for 2-Hexadecynoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 2-Hexadecynoic acid through regulating the expression of Fatty acid synthase (FASN). [2], [3]
References
Ref 1 Fat mass and obesity-associated protein regulates lipogenesis via m(6) A modification in fatty acid synthase mRNA. Cell Biol Int. 2021 Feb;45(2):334-344. doi: 10.1002/cbin.11490. Epub 2020 Nov 8.
Ref 2 Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. doi: 10.1016/S1130-1406(09)70004-X. Epub 2009 May 7.
Ref 3 METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism. Biochem Biophys Res Commun. 2019 Oct 8;518(1):120-126. doi: 10.1016/j.bbrc.2019.08.018. Epub 2019 Aug 10.