m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00731)
Name
Englitazone sodium
Synonyms
Englitazone sodium < Rec INNM; CP-68722 (racemate); CP-72467-02; CP-72467-2; (-)-5-[2(R)-Benzyl-3,4-dihydro-2H-benzopyran-6-ylmethyl]thiazolidine-2,4-dione sodium salt
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Status
Phase 1
Structure
3D MOL
2D MOL
Formula
C20H18NNaO3S
InChI
1S/C20H19NO3S.Na/c22-19-18(25-20(23)21-19)12-14-6-9-17-15(10-14)7-8-16(24-17)11-13-4-2-1-3-5-13;/h1-6,9-10,16,18H,7-8,11-12H2,(H,21,22,23);/q;+1/p-1/t16-,18?;/m1./s1
InChIKey
JQWYNJRCVYGLMO-GPPXSFHXSA-M
PubChem CID
13728795
TTD Drug ID
D08EEU
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a therapeutic target for Englitazone sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Englitazone sodium through regulating the expression of Peroxisome proliferator-activated receptor gamma (PPAR-gamma). [1], [2]
References
Ref 1 The m(6)A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG. Acta Pharmacol Sin. 2022 May;43(5):1311-1323. doi: 10.1038/s41401-021-00756-8. Epub 2021 Aug 30.
Ref 2 Effects of DSP-8658, a novel selective peroxisome proliferator-activated receptors a/Gamma modulator, on adipogenesis and glucose metabolism in diabetic obese mice. Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):492-9. doi: 10.1055/s-0035-1549965. Epub 2015 May 26.