m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00656)
Name
7-Methyl-Guanosine-5'-Triphosphate
Status
Investigative
Structure
3D MOL
2D MOL
Formula
C11H19N5O14P3+
InChI
1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p+1/t4-,6-,7-,10-/m1/s1
InChIKey
DKVRNHPCAOHRSI-KQYNXXCUSA-O
PubChem CID
135419182
TTD Drug ID
D00FPT
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
EIF4E messenger RNA (EIF4E mRNA)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary EIF4E messenger RNA (EIF4E mRNA) is a therapeutic target for 7-Methyl-Guanosine-5'-Triphosphate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 7-Methyl-Guanosine-5'-Triphosphate through regulating the expression of EIF4E messenger RNA (EIF4E mRNA). [1], [2]
References
Ref 1 The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.
Ref 2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.