m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG00624)
| Name |
ADU-S100
|
||||
|---|---|---|---|---|---|
| Synonyms |
MIW815; IZJJFUQKKZFVLH-LTKSHMRXSA-N; 1638241-89-0; AKOS027321070; HY-12885
Click to Show/Hide
|
||||
| Status |
Phase 2
|
||||
| Structure |
 |
||||
|
3D MOL
|
|||||
| Formula |
C20H22N10Na2O10P2S2
|
||||
| InChI |
1S/C20H24N10O10P2S2.2Na/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30;;/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26);;/q;2*+1/p-2/t7-,8-,11-,12-,13-,14-,19-,20-,41?,42?;;/m1../s1
|
||||
| InChIKey |
GDWOOOCBNOMMTL-QYUKNOIISA-L
|
||||
| PubChem CID | |||||
| TTD Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Stimulator of interferon genes protein (TMEM173)
RNA demethylase ALKBH5 (ALKBH5)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Stimulator of interferon genes protein (TMEM173) is a therapeutic target for ADU-S100. The RNA demethylase ALKBH5 (ALKBH5) has potential in affecting the response of ADU-S100 through regulating the expression of Stimulator of interferon genes protein (TMEM173). | [1], [2] | ||
References