m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00403)
Name
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid
Synonyms
CHEMBL202875; 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid
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Status
Investigative
Structure
Formula
C20H18O3
InChI
1S/C20H18O3/c1-2-17(14-19(21)22)20(23)18-12-10-16(11-13-18)9-8-15-6-4-3-5-7-15/h3-7,10-13,17H,2,14H2,1H3,(H,21,22)
InChIKey
OQWWYXZJKRAMIK-UHFFFAOYSA-N
PubChem CID
11609208
TTD Drug ID
D0L4EO
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Matrix metalloproteinase-12 (MMP-12)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-12 (MMP-12) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-12 (MMP-12). [1], [2]
Matrix metalloproteinase-2 (MMP-2)
E3 ubiquitin-protein ligase Hakai (CBLL1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The E3 ubiquitin-protein ligase Hakai (CBLL1) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [3], [4]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-2 (MMP-2) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-2 (MMP-2). [4], [5]
Matrix metalloproteinase-9 (MMP-9)
E3 ubiquitin-protein ligase Hakai (CBLL1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The E3 ubiquitin-protein ligase Hakai (CBLL1) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [3], [6]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid through regulating the expression of Matrix metalloproteinase-9 (MMP-9). [1], [6]
References
Ref 1 The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell Biol Toxicol. 2022 Feb;38(1):167-183. doi: 10.1007/s10565-021-09585-1. Epub 2021 Mar 4.
Ref 2 Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. doi: 10.1021/jm051101g.
Ref 3 CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion. Thorac Cancer. 2019 Jun;10(6):1479-1488. doi: 10.1111/1759-7714.13097. Epub 2019 May 23.
Ref 4 Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3096-100. doi: 10.1016/j.bmcl.2006.03.065. Epub 2006 May 2.
Ref 5 RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2. Melanoma Res. 2019 Aug;29(4):382-389. doi: 10.1097/CMR.0000000000000580.
Ref 6 Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3105-10. doi: 10.1016/j.bmcl.2006.03.077. Epub 2006 Apr 17.