m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00293)
Name
Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-)
Synonyms
CHEMBL219339; cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-)
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Status
Investigative
Structure
3D MOL
2D MOL
Formula
C36H47N11O6
InChI
1S/C36H47N11O6/c37-35(38)41-15-3-7-26-32(51)45-27(8-4-16-42-36(39)40)33(52)47-28(18-21-10-13-25(48)14-11-21)31(50)43-20-30(49)44-29(34(53)46-26)19-22-9-12-23-5-1-2-6-24(23)17-22/h1-2,5-6,9-14,17,26-29,48H,3-4,7-8,15-16,18-20H2,(H,43,50)(H,44,49)(H,45,51)(H,46,53)(H,47,52)(H4,37,38,41)(H4,39,40,42)/t26-,27+,28+,29-/m0/s1
InChIKey
YASYVKCWJGCXLS-AUAHOFGGSA-N
PubChem CID
11331592
TTD Drug ID
D0ZO3C
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
C-X-C chemokine receptor type 4 (CXCR4)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-). The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-). The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [2], [3]
YTH domain-containing family protein 2 (YTHDF2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary C-X-C chemokine receptor type 4 (CXCR4) is a therapeutic target for Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-). The YTH domain-containing family protein 2 (YTHDF2) has potential in affecting the response of Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) through regulating the expression of C-X-C chemokine receptor type 4 (CXCR4). [1], [2]
References
Ref 1 m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 Jun 25;10(1):2782. doi: 10.1038/s41467-019-10669-0.
Ref 2 Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4124-9. doi: 10.1016/j.bmcl.2008.05.092. Epub 2008 May 29.
Ref 3 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.