m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00200)
Name
Phenethyl-(4-phenyl-butyl)-amine
Synonyms
CHEMBL280111; Phenethyl-(4-phenyl-butyl)-amine; SCHEMBL8084143; 4-Phenyl-N-phenethyl-1-butanamine; ZINC13736042
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Status
Investigative
Structure
Formula
C18H23N
InChI
1S/C18H23N/c1-3-9-17(10-4-1)13-7-8-15-19-16-14-18-11-5-2-6-12-18/h1-6,9-12,19H,7-8,13-16H2
InChIKey
HMGFNEMDDFFJES-UHFFFAOYSA-N
PubChem CID
10708590
TTD Drug ID
D0J1AE
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Glutamate receptor ionotropic NMDA 1 (NMDAR1)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Glutamate receptor ionotropic NMDA 1 (NMDAR1) is a therapeutic target for Phenethyl-(4-phenyl-butyl)-amine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Phenethyl-(4-phenyl-butyl)-amine through regulating the expression of Glutamate receptor ionotropic NMDA 1 (NMDAR1). [1], [2]
References
Ref 1 Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. ACS Chem Neurosci. 2019 May 15;10(5):2355-2363. doi: 10.1021/acschemneuro.8b00657. Epub 2019 Mar 14.
Ref 2 Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. doi: 10.1021/jm980235+.