m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00049)
Name
N1,N3-bis(3-methoxybenzyl)isophthalamide
Synonyms
CHEMBL605201; N1,N3-bis(3-methoxybenzyl)isophthalamide; SCHEMBL5332068
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Status
Investigative
Structure
Formula
C24H24N2O4
InChI
1S/C24H24N2O4/c1-29-21-10-3-6-17(12-21)15-25-23(27)19-8-5-9-20(14-19)24(28)26-16-18-7-4-11-22(13-18)30-2/h3-14H,15-16H2,1-2H3,(H,25,27)(H,26,28)
InChIKey
XDBOLPFDJWTESQ-UHFFFAOYSA-N
PubChem CID
10111838
TTD Drug ID
D04GOO
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Matrix metalloproteinase-13 (MMP-13)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N1,N3-bis(3-methoxybenzyl)isophthalamide. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of N1,N3-bis(3-methoxybenzyl)isophthalamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for N1,N3-bis(3-methoxybenzyl)isophthalamide. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of N1,N3-bis(3-methoxybenzyl)isophthalamide through regulating the expression of Matrix metalloproteinase-13 (MMP-13). [2], [3]
References
Ref 1 FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13. Exp Cell Res. 2020 Apr 1;389(1):111894. doi: 10.1016/j.yexcr.2020.111894. Epub 2020 Feb 6.
Ref 2 Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13. Bioorg Med Chem Lett. 2009 Jan 1;19(1):47-50. doi: 10.1016/j.bmcl.2008.11.038. Epub 2008 Nov 18.
Ref 3 METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. Biochem Biophys Res Commun. 2019 Aug 13;516(1):22-27. doi: 10.1016/j.bbrc.2019.05.168. Epub 2019 Jun 8.