m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0173)
Name
Cerebrovascular diseases
ICD
ICD-11: 8B22
Full List of Target Gene(s) of This m6A-centered Disease Response
Mammalian target of rapamycin complex 2 (mTORC2)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary WTAP has been identified as a key subunit of the m6A methyltransferase complex, was down-regulated in brain arteriovenous malformations (AVMs) lesions.
Responsed Disease Arteriovenous malformation of cerebral vessels [ICD-11: 8B22.40]
Target Regulator Wilms tumor 1-associating protein (WTAP) WRITER
 Regulator Info 
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary The expression level of METTL3 was reduced in the larger pathological tissues of cerebral arteriovenous malformation (AVM). Moreover, knockdown of METTL3 significantly affected angiogenesis of the human endothelial cells.
Responsed Disease Arteriovenous malformation of cerebral vessels [ICD-11: 8B22.40]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Pathway Response Notch signaling pathway hsa04330
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
References
Ref 1 Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation. J Cell Mol Med. 2020 May;24(9):4981-4991. doi: 10.1111/jcmm.15101. Epub 2020 Apr 13.
Ref 2 N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway. J Biomed Sci. 2020 May 9;27(1):62. doi: 10.1186/s12929-020-00655-w.