Name	Gastrointestinal cancer
ICD	ICD-11: 2C11

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	m6A regulators were mostly upregulated in Gastrointestinal cancer and their differential expression significantly influenced the overall survival of patients with GI cancer. The PI3-kinase subunit alpha (PI3k/PIK3CA)/Akt and mammalian target of rapamycin (mTOR) signaling pathways were found to be potentially affected by m6A modification in most human cancers, including GI cancer, which was further verified by m6A-Seq and phospho-MAPK array.
Responsed Disease	Gastrointestinal cancer [ICD-11: 2C11]
Pathway Response	PI3K-Akt signaling pathway			hsa04151), mTOR signaling pathway
In-vitro Model	TMK-1	Gastric adenocarcinoma	Homo sapiens	CVCL_4384
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens	CVCL_0480
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	m6A regulators were mostly upregulated in Gastrointestinal cancer and their differential expression significantly influenced the overall survival of patients with GI cancer. The phosphatidylinositol-3-kinase (PI3K)/RAC-alpha serine/threonine-protein kinase (AKT1) and mammalian target of rapamycin (mTOR) signaling pathways were found to be potentially affected by m6A modification in most human cancers, including GI cancer, which was further verified by m6A-Seq and phospho-MAPK array.
Responsed Disease	Gastrointestinal cancer [ICD-11: 2C11]
Pathway Response	PI3K-Akt signaling pathway			hsa04151), mTOR signaling pathway
In-vitro Model	TMK-1	Gastric adenocarcinoma	Homo sapiens	CVCL_4384
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens	CVCL_0480
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	m6A regulators were mostly upregulated in Gastrointestinal cancer and their differential expression significantly influenced the overall survival of patients with GI cancer. The phosphatidylinositol-3-kinase (PI3K)/Akt and mammalian target of rapamycin Serine/threonine-protein kinase mTOR (MTOR) signaling pathways were found to be potentially affected by m6A modification in most human cancers, including GI cancer, which was further verified by m6A-Seq and phospho-MAPK array.
Responsed Disease	Gastrointestinal cancer [ICD-11: 2C11]
Pathway Response	PI3K-Akt signaling pathway			hsa04151), mTOR signaling pathway
In-vitro Model	TMK-1	Gastric adenocarcinoma	Homo sapiens	CVCL_4384
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens	CVCL_0480
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291

Ref 1	m(6)A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer. Theranostics. 2020 Jul 25;10(21):9528-9543. doi: 10.7150/thno.42971. eCollection 2020.