m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0134)
Name
Acute respiratory distress syndrome
ICD
ICD-11: CB00
Full List of Target Gene(s) of This m6A-centered Disease Response
hsa-miR-29a-3p
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The knockout of methyltransferase 3 (N6-adenosine-methyltransferase complex catalytic subunit) removed the m6A modification of hsa-miR-29a-3p and reduced miR-29a-3p expression. These findings suggest that miR-29a-3p is a potential target that can be manipulated for ALI/ARDS.
Responsed Disease Acute respiratory distress syndrome [ICD-11: CB00]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
In-vivo Model All the mice were randomly divided into three groups: the normal saline group (NS), the lipopolysaccharide + negative control group (LPS + NC), and the LPS + miR-29a-3p agomir group (LPS + Agomir).
References
Ref 1 MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis. Aging Dis. 2022 Jun 1;13(3):899-909. doi: 10.14336/AD.2021.1023. eCollection 2022 Jun.