m6A-centered Disease Response Information | M6AREG

General Information of the Disease (ID: M6ADIS0132)

Name	Keloid
ICD	ICD-11: EE60

Full List of Target Gene(s) of This m6A-centered Disease Response

Transforming growth factor beta-1 proprotein (TGFB1)

Target Info

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	Pregulation of eIF3a mRNA and protein and in human keloid tissues compared with in normal tissues. Knockdown of eIF3a inhibited KF proliferation induced by Transforming growth factor beta-1 proprotein (TGFB1).
Responsed Disease	Keloid [ICD-11: EE60.0]
Target Regulator	Eukaryotic initiation factor 3 (EIF3A)		READER	Regulator Info
Pathway Response	TGF-beta signaling pathway			hsa04350
In-vitro Model	Responsive keloid fibroblasts (Isolated from skin keloid tissue)

References

Ref 1	Knockdown of elF3a inhibits TGF?Beta1?induced extracellular matrix protein expression in keloid fibroblasts. Mol Med Rep. 2018 Mar;17(3):4057-4061. doi: 10.3892/mmr.2017.8365. Epub 2017 Dec 29.

Cite M6AREG

S. P. Liu, L. Chen, Y. T. Zhang, Y. Zhou, Y. He, Z. Chen, S. S. Qi, J. Y. Zhu, X. D. Chen, H. Zhang, Y. C. Luo, Y. Q. Qiu, L. Tao*, F. Zhu*. M6AREG: m6A-centered regulation of disease development and drug response. Nucleic Acids Research. 2022 Sep 22;gkac801. PMID: 36134713

Correspondence

Prof. Feng ZHU

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Prof. Shuiping Liu

School of Pharmacy, Hangzhou Normal University, Hangzhou, China

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