m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0121)

Name	Cerebral development anomalies
ICD	ICD-11: LA05

Full List of Target Gene(s) of This m6A-centered Disease Response

Cellular tumor antigen p53 (TP53/p53)

Target Info

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene		[1]
Response Summary	Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of Cellular tumor antigen p53 (TP53/p53) signaling. N6-methyladenosine (m6A) methylation-mediated degradation of RNA is essential for brain development,m6A methylation impacts not only RNA stability, but also other RNA metabolism processes. Exosc10 in suppressing the P53 pathway, in which the rapid turnover of the apoptosis effectors Aen and Bbc3 mRNAs is essential for cell survival and normal cortical histogenesis.
Responsed Disease	Cerebral development anomalies [ICD-11: LA05]
Pathway Response	p53 signaling pathway	hsa04115
	Apoptosis	hsa04210
Cell Process	Cell apoptosis
In-vivo Model	Exosc10cKO_Emx1-Cre mouse embryos were subjected to the p53-inhibitor Pifithrin-Alpha (PFT-Alpha) by intraperitoneal injection of 2.2 mg/kg PFT-Alpha (Selleckchem) into the pregnant mother at between E9.5 and E12.5 or between E9.5 and E15.5. Embryonic brains were isolated at E13.5 or E18.5 and immunohistochemistry was performed.

Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1/eIF2-Alpha)

Target Info

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene		[2]
Response Summary	Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barre syndrome and microcephaly. This review summarizes relevant aspects of the complex crosstalk between RNA metabolism and cellular stress responses against ZIKV and discusses their possible impact on viral pathogenesis. ZIKV replication is known to induce cellular stress, which triggers both the expression of innate immune genes and the phosphorylation of eukaryotic translation initiation factor 2 (eIF2-alpha), shutting-off host protein synthesis.
Responsed Disease	Microcephaly [ICD-11: LA05.0]
Pathway Response	Apoptosis	hsa04210
Cell Process	Cellular Stress Responses
	Cell apoptosis

References

Ref 1	Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Development. 2021 Feb 8;148(3):dev188276. doi: 10.1242/dev.188276.
Ref 2	Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication. Pathogens. 2020 Feb 25;9(3):158. doi: 10.3390/pathogens9030158.