m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0098)
Name
Acute coronary syndrome
ICD
ICD-11: BA4Z
Full List of Target Gene(s) of This m6A-centered Disease Response
hsa_circ_0029589
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome.
Responsed Disease Acute coronary syndrome [ICD-11: BA4Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Macrophage pyroptosis
In-vitro Model CD14 + cells (CD14+ cells from human peripheral blood)
References
Ref 1 IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome. Int Immunopharmacol. 2020 Sep;86:106800. doi: 10.1016/j.intimp.2020.106800. Epub 2020 Jul 13.