m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01734)
Target Name Interleukin-18 (IL18)
Synonyms
IL-18; Iboctadekin; Interferon gamma-inducing factor; Interleukin-1 gamma; IFN-gamma-inducing factor; IL-1 gamma
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Gene Name IL18
Chromosomal Location 11q23.1
Family IL-1 family
Function
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
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Gene ID 3606
Uniprot ID
IL18_HUMAN
HGNC ID
HGNC:5986
KEGG ID
hsa:3606
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05191
 Crosstalk Info 
Epigenetic Regulator hsa-miR-381
Regulated Target YTH domain-containing family protein 1 (YTHDF1)
Crosstalk relationship ncRNA → m6A
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01734)
Interleukin-18 (IL18)
5-methylcytidine (m5C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005369 Click to Show/Hide the Full List
mod site chr11:112143528-112143529:-
Sequence AGCCCTTTGGGAGGCTGAGGCGGGCAGATCACCAGAGGTCA
Cell/Tissue List liver; spleen
Seq Type List Bisulfite-seq
Transcript ID List rmsk_3659225; ENST00000525547.5; ENST00000280357.12; ENST00000524595.5
External Link RMBase: m5C_site_8948
mod ID: M5CSITE005370 Click to Show/Hide the Full List
mod site chr11:112143534-112143535:-
Sequence AATCCCAGCCCTTTGGGAGGCTGAGGCGGGCAGATCACCAG
Cell/Tissue List liver; spleen
Seq Type List Bisulfite-seq
Transcript ID List ENST00000525547.5; rmsk_3659225; ENST00000280357.12; ENST00000524595.5
External Link RMBase: m5C_site_8949
N6-methyladenosine (m6A)
In total 24 m6A sequence/site(s) in this target gene
mod ID: M6ASITE008688 Click to Show/Hide the Full List
mod site chr11:112143274-112143275:- [2]
Sequence AAAATAAAATAAATAAATAAACAAATAAAAAATTCATAATG
Motif Score 2.20572619
Cell/Tissue List A549
Seq Type List m6A-seq
Transcript ID List ENST00000280357.12; ENST00000525547.5; ENST00000524595.5; rmsk_3659225
External Link RMBase: m6A_site_163816
mod ID: M6ASITE008689 Click to Show/Hide the Full List
mod site chr11:112143306-112143307:- [2]
Sequence GCCTGGGCAACAACAGCAAAACTCCATCTCAAAAAATAAAA
Motif Score 2.627720238
Cell/Tissue List A549
Seq Type List m6A-seq
Transcript ID List ENST00000524595.5; ENST00000280357.12; rmsk_3659225; ENST00000525547.5
External Link RMBase: m6A_site_163817
mod ID: M6ASITE008690 Click to Show/Hide the Full List
mod site chr11:112143599-112143600:- [3]
Sequence GTTCACTGTTCAAAACGAAGACTAGCTATTAAAATTTCATG
Motif Score 3.319380952
Cell/Tissue List HeLa; A549; Huh7; HEC-1-A
Seq Type List m6A-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List ENST00000525547.5; ENST00000524595.5; ENST00000528832.1; ENST00000280357.12
External Link RMBase: m6A_site_163818
mod ID: M6ASITE008691 Click to Show/Hide the Full List
mod site chr11:112143664-112143665:- [3]
Sequence AAAGAGAGAGACCTTTTTAAACTCATTTTGAAAAAAGAGGA
Motif Score 2.627720238
Cell/Tissue List HeLa; A549; Huh7; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000528832.1; ENST00000280357.12; ENST00000525547.5; ENST00000524595.5
External Link RMBase: m6A_site_163819
mod ID: M6ASITE008692 Click to Show/Hide the Full List
mod site chr11:112143674-112143675:- [3]
Sequence AGCTTGTGAAAAAGAGAGAGACCTTTTTAAACTCATTTTGA
Motif Score 2.876744048
Cell/Tissue List HeLa; A549; Huh7; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000528832.1; ENST00000524595.5; ENST00000525547.5; ENST00000280357.12
External Link RMBase: m6A_site_163820
mod ID: M6ASITE008693 Click to Show/Hide the Full List
mod site chr11:112143745-112143746:- [3]
Sequence TTTCAGAGAAGTGTCCCAGGACATGATAATAAGATGCAATT
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000525547.5; ENST00000524595.5; ENST00000533858.5; ENST00000280357.12; ENST00000528832.1
External Link RMBase: m6A_site_163821
mod ID: M6ASITE008694 Click to Show/Hide the Full List
mod site chr11:112148621-112148622:- [3]
Sequence TTCAACTCTCTCCTGTGAGAACAAAATTATTTCCTTTAAGG
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000528832.1; ENST00000525547.5; ENST00000280357.12; ENST00000533858.5; ENST00000524595.5
External Link RMBase: m6A_site_163822
mod ID: M6ASITE008695 Click to Show/Hide the Full List
mod site chr11:112148721-112148722:- [3]
Sequence TTTCAGATAATGCACCCCGGACCATATTTATTATAAGTATG
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000533858.5; ENST00000525547.5; ENST00000280357.12; ENST00000528832.1; ENST00000524595.5
External Link RMBase: m6A_site_163823
mod ID: M6ASITE008696 Click to Show/Hide the Full List
mod site chr11:112150202-112150203:- [3]
Sequence TTTAATGTTTATTGTAGAAAACCTGGAATCAGATTACTTTG
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000524595.5; ENST00000280357.12; ENST00000525547.5; ENST00000533858.5; ENST00000528832.1
External Link RMBase: m6A_site_163824
mod ID: M6ASITE008697 Click to Show/Hide the Full List
mod site chr11:112150447-112150448:- [4]
Sequence GAAAACTAGAAGGGTAAGAGACCGGTCAGAAAGTAGGCTAT
Motif Score 2.876744048
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000533858.5; ENST00000528832.1; ENST00000524595.5; ENST00000280357.12; ENST00000525547.5
External Link RMBase: m6A_site_163825
mod ID: M6ASITE008698 Click to Show/Hide the Full List
mod site chr11:112150463-112150464:- [3]
Sequence TGGAGTAAAAGTGTAAGAAAACTAGAAGGGTAAGAGACCGG
Motif Score 2.627720238
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000533858.5; ENST00000524595.5; ENST00000528832.1; ENST00000280357.12; ENST00000525547.5
External Link RMBase: m6A_site_163826
mod ID: M6ASITE008699 Click to Show/Hide the Full List
mod site chr11:112150494-112150495:- [3]
Sequence AGATGTTGTGAAATTTAAGAACACATAGAGTTGGAGTAAAA
Motif Score 2.951386905
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000533858.5; ENST00000528832.1; ENST00000525547.5; ENST00000280357.12; ENST00000524595.5
External Link RMBase: m6A_site_163827
mod ID: M6ASITE008700 Click to Show/Hide the Full List
mod site chr11:112150520-112150521:- [3]
Sequence GGAAATACAAGAGTCAGGAGACTGGAAGATGTTGTGAAATT
Motif Score 3.319380952
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000528832.1; ENST00000533858.5; ENST00000525547.5; ENST00000280357.12; ENST00000524595.5
External Link RMBase: m6A_site_163828
mod ID: M6ASITE008701 Click to Show/Hide the Full List
mod site chr11:112150594-112150595:- [4]
Sequence CAAAATGGTAGACAAAATGAACTCTGAGATCCAGCTGCACA
Motif Score 3.373380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000280357.12; ENST00000525547.5; ENST00000533858.5; ENST00000528832.1; ENST00000524595.5
External Link RMBase: m6A_site_163829
mod ID: M6ASITE008702 Click to Show/Hide the Full List
mod site chr11:112150603-112150604:- [4]
Sequence ATATCCTGGCAAAATGGTAGACAAAATGAACTCTGAGATCC
Motif Score 2.897386905
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000280357.12; ENST00000524595.5; ENST00000533858.5; ENST00000525547.5; ENST00000528832.1
External Link RMBase: m6A_site_163830
mod ID: M6ASITE008703 Click to Show/Hide the Full List
mod site chr11:112150643-112150644:- [4]
Sequence TGGAGTTTTGTAGCAGAAAGACAAATAAGTTAGGGATTTAA
Motif Score 2.897386905
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000524595.5; ENST00000525547.5; ENST00000533858.5; ENST00000528832.1; ENST00000280357.12
External Link RMBase: m6A_site_163831
mod ID: M6ASITE008704 Click to Show/Hide the Full List
mod site chr11:112150754-112150755:- [3]
Sequence AGAGAGTGCTGAACTGGAAAACAAAAGAAGTATTGACAATT
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000280357.12; ENST00000525547.5; ENST00000533858.5; ENST00000524595.5; ENST00000528832.1
External Link RMBase: m6A_site_163832
mod ID: M6ASITE008705 Click to Show/Hide the Full List
mod site chr11:112150762-112150763:- [3]
Sequence GCTATGGAAGAGAGTGCTGAACTGGAAAACAAAAGAAGTAT
Motif Score 3.373380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000524595.5; ENST00000533858.5; ENST00000528832.1; ENST00000280357.12; ENST00000525547.5
External Link RMBase: m6A_site_163833
mod ID: M6ASITE008706 Click to Show/Hide the Full List
mod site chr11:112153086-112153087:- [3]
Sequence GAGGCCAAAAGCTGAAAGAAACCATGGCATTTATGATGAAT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000534225.1; ENST00000533858.5; ENST00000528832.1; ENST00000280357.12; ENST00000524595.5
External Link RMBase: m6A_site_163834
mod ID: M6ASITE008707 Click to Show/Hide the Full List
mod site chr11:112153116-112153117:- [3]
Sequence GGAATGGGTGGGGCAAGAAGACCACATTCAGAGGCCAAAAG
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000533858.5; ENST00000528832.1; ENST00000534225.1; ENST00000524595.5; ENST00000280357.12
External Link RMBase: m6A_site_163835
mod ID: M6ASITE008708 Click to Show/Hide the Full List
mod site chr11:112153341-112153342:- [4]
Sequence TCTTAGAATCTACAAAATAGACTTTGCCTGTTTCATAGGTC
Motif Score 3.319380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000524595.5; ENST00000533858.5; ENST00000534225.1; ENST00000280357.12; ENST00000528832.1
External Link RMBase: m6A_site_163836
mod ID: M6ASITE008709 Click to Show/Hide the Full List
mod site chr11:112153407-112153408:- [3]
Sequence CATAAGAGATACAAAGAAGAACCTCTAGCAAAAGATGCTTC
Motif Score 2.930744048
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000534225.1; ENST00000524595.5; ENST00000533858.5; ENST00000528832.1; ENST00000280357.12
External Link RMBase: m6A_site_163837
mod ID: M6ASITE008710 Click to Show/Hide the Full List
mod site chr11:112153459-112153460:- [3]
Sequence CTGCCTTCAAAGAAATGTGGACTCAGTAGCACAGCTTTGGA
Motif Score 4.065041667
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000533858.5; ENST00000280357.12; ENST00000534225.1; ENST00000524595.5; ENST00000528832.1
External Link RMBase: m6A_site_163838
mod ID: M6ASITE008711 Click to Show/Hide the Full List
mod site chr11:112153539-112153540:- [3]
Sequence AAACTAAGTATCTGCTTGAGACACATCTATCTCACCATTGT
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000280357.12; ENST00000534225.1; ENST00000528832.1; ENST00000533858.5; ENST00000524595.5
External Link RMBase: m6A_site_163839