m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01577)
Target Name Methyl-CpG-binding protein 2 (MECP2)
Synonyms
MeCp-2 protein; MeCp2
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Gene Name MeCP2
Chromosomal Location Xq28
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
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Gene ID 4204
Uniprot ID
MECP2_HUMAN
HGNC ID
HGNC:6990
KEGG ID
hsa:4204
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
DNA modification
m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02108
 Crosstalk Info 
Epigenetic Regulator Methyl-CpG-binding protein 2 (MECP2)
Regulated Target Solute carrier family 31 member 1 (SLC31A1)
Crosstalk relationship m6A → DNA modification
Disease Vascular disorders of the liver
 Disease Info 
References
Ref 1 Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial. PLoS One. 2014; 9(12): e113465.