m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01515)

Target Name	Glutaredoxin-1 (GLRX)
Synonyms	Thioltransferase-1; TTase-1 Click to Show/Hide
Gene Name	GLRX
Chromosomal Location	5q15
Family	Glutaredoxin family
Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Click to Show/Hide
Gene ID	2745
Uniprot ID	GLRX1_HUMAN
HGNC ID	HGNC:4330
KEGG ID	hsa:2745

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01515)

Glutaredoxin-1 (GLRX)

Adenosine-to-Inosine editing (A-to-I)

In total 7 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000764		Click to Show/Hide the Full List
mod site	chr5:95782533-95782534:-		[2]
Sequence	TTACAGGCATGAGCCGCCACATCCGGCCCATTTTAACCACT
Transcript ID List	ENST00000508780.5; ENST00000507605.1
External Link	RMBase: RNA-editing_site_110435
mod ID: A2ISITE000765		Click to Show/Hide the Full List
mod site	chr5:95782614-95782615:-		[3]
Sequence	GGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGA
Transcript ID List	ENST00000507605.1; ENST00000508780.5
External Link	RMBase: RNA-editing_site_110436
mod ID: A2ISITE000766		Click to Show/Hide the Full List
mod site	chr5:95782618-95782619:-		[3]
Sequence	AGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTC
Transcript ID List	ENST00000507605.1; ENST00000508780.5
External Link	RMBase: RNA-editing_site_110437
mod ID: A2ISITE000767		Click to Show/Hide the Full List
mod site	chr5:95782626-95782627:-		[3]
Sequence	TTTTGTAAAGACGGGGTTTCACCGTGTTAGCCAGGATGGTC
Transcript ID List	ENST00000508780.5; ENST00000507605.1
External Link	RMBase: RNA-editing_site_110438
mod ID: A2ISITE000768		Click to Show/Hide the Full List
mod site	chr5:95782677-95782678:-		[3]
Sequence	AGCTGGGAGCACAGGCGCCCACCACCACGCCCGGCTAATTT
Transcript ID List	ENST00000508780.5; ENST00000507605.1
External Link	RMBase: RNA-editing_site_110439
mod ID: A2ISITE000769		Click to Show/Hide the Full List
mod site	chr5:95782687-95782688:-		[3]
Sequence	CCTCCTGAGGAGCTGGGAGCACAGGCGCCCACCACCACGCC
Transcript ID List	ENST00000508780.5; ENST00000507605.1
External Link	RMBase: RNA-editing_site_110440
mod ID: A2ISITE000770		Click to Show/Hide the Full List
mod site	chr5:95782805-95782806:-		[2]
Sequence	TTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGTC
Transcript ID List	ENST00000507605.1; ENST00000508780.5
External Link	RMBase: RNA-editing_site_110441

N6-methyladenosine (m6A)

In total 16 m6A sequence/site(s) in this target gene
mod ID: M6ASITE069676		Click to Show/Hide the Full List
mod site	chr5:95813988-95813989:-		[4]
Sequence	TTTCTTTTCTAATAAAAAAAACCTATAGATGATTCAGTGAT
Motif Score	2.185083333
Cell/Tissue List	LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000379979.8; ENST00000507605.1; ENST00000237858.11; ENST00000508780.5; ENST00000507412.1
External Link	RMBase: m6A_site_677396
mod ID: M6ASITE069677		Click to Show/Hide the Full List
mod site	chr5:95814019-95814020:-		[5]
Sequence	ATTTCCTTCAATCTCTAGTGACAACACTTAATTTCTTTTCT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000507412.1; ENST00000379979.8; ENST00000508780.5; ENST00000507605.1; ENST00000237858.11
External Link	RMBase: m6A_site_677397
mod ID: M6ASITE069678		Click to Show/Hide the Full List
mod site	chr5:95814093-95814094:-		[6]
Sequence	AGAGCTCCTACACTTTGAAAACTTAAGAATCCCTTATCATG
Motif Score	2.627720238
Cell/Tissue List	HeLa; LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000508780.5; ENST00000507412.1; ENST00000507605.1; ENST00000379979.8; ENST00000237858.11
External Link	RMBase: m6A_site_677398
mod ID: M6ASITE069679		Click to Show/Hide the Full List
mod site	chr5:95814104-95814105:-		[5]
Sequence	GTATCTGTGAAAGAGCTCCTACACTTTGAAAACTTAAGAAT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000379979.8; ENST00000508780.5; ENST00000507605.1; ENST00000507412.1; ENST00000237858.11
External Link	RMBase: m6A_site_677399
mod ID: M6ASITE069680		Click to Show/Hide the Full List
mod site	chr5:95814149-95814150:-		[6]
Sequence	AATGTAAAACATCTGATAAAACTTACAGCCCCCTACACCAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000237858.11; ENST00000508780.5; ENST00000507412.1; ENST00000507605.1; ENST00000379979.8
External Link	RMBase: m6A_site_677400
mod ID: M6ASITE069681		Click to Show/Hide the Full List
mod site	chr5:95814161-95814162:-		[6]
Sequence	ATTAAAGCATGAAATGTAAAACATCTGATAAAACTTACAGC
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T; LCLs
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000507605.1; ENST00000237858.11; ENST00000379979.8; ENST00000508780.5; ENST00000507412.1
External Link	RMBase: m6A_site_677401
mod ID: M6ASITE069682		Click to Show/Hide the Full List
mod site	chr5:95814194-95814195:-		[6]
Sequence	TGTGTATTTATTTTATTTAGACTACCAGCAAAGATTAAAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; LCLs
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000237858.11; ENST00000507412.1; ENST00000507605.1; ENST00000379979.8; ENST00000508780.5
External Link	RMBase: m6A_site_677402
mod ID: M6ASITE069683		Click to Show/Hide the Full List
mod site	chr5:95814218-95814219:-		[6]
Sequence	GGCTATCCAGATAATCCTGAACACTGTGTATTTATTTTATT
Motif Score	2.951386905
Cell/Tissue List	HeLa; liver; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; m6A-REF-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000507412.1; ENST00000237858.11; ENST00000379979.8; ENST00000508780.5; ENST00000507605.1
External Link	RMBase: m6A_site_677403
mod ID: M6ASITE069684		Click to Show/Hide the Full List
mod site	chr5:95814257-95814258:-		[6]
Sequence	AGAGGCTGTGGTCATGCGGAACACTCTGTTATTTAAGATGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; liver
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000507412.1; ENST00000507605.1; ENST00000237858.11; ENST00000508780.5; ENST00000379979.8
External Link	RMBase: m6A_site_677404
mod ID: M6ASITE069685		Click to Show/Hide the Full List
mod site	chr5:95814285-95814286:-		[5]
Sequence	GTGTCATATGGATCAGAGGCACAAGTGCAGAGGCTGTGGTC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000379979.8; ENST00000237858.11; ENST00000507605.1; ENST00000508780.5; ENST00000507412.1
External Link	RMBase: m6A_site_677405
mod ID: M6ASITE069686		Click to Show/Hide the Full List
mod site	chr5:95814744-95814745:-		[6]
Sequence	TGCTCTTTGGTTTTCAGAAGACTGTGACAAGTTCTGGCCCA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000507412.1; ENST00000505427.1; ENST00000507605.1; ENST00000379979.8; ENST00000237858.11; ENST00000508780.5
External Link	RMBase: m6A_site_677406
mod ID: M6ASITE069687		Click to Show/Hide the Full List
mod site	chr5:95822469-95822470:-		[7]
Sequence	AAGATTATTTGCAACAGCTCACGGGAGCAAGAACGGTGAGT
Motif Score	2.021232143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000379979.8; ENST00000237858.11; ENST00000505427.1; ENST00000512469.2; ENST00000508780.5
External Link	RMBase: m6A_site_677407
mod ID: M6ASITE069688		Click to Show/Hide the Full List
mod site	chr5:95822517-95822518:-		[8]
Sequence	TTCTGGAATTTGTCGATATCACAGCCACCAACCACACTAAC
Motif Score	2.047297619
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000237858.11; ENST00000379979.8; ENST00000508780.5; ENST00000512469.2; ENST00000505427.1
External Link	RMBase: m6A_site_677408
mod ID: M6ASITE069689		Click to Show/Hide the Full List
mod site	chr5:95822545-95822546:-		[9]
Sequence	CTCAGTCAATTGCCCATCAAACAAGGGCTTCTGGAATTTGT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; A549; hESC-HEK293T; Jurkat; CD4T; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000237858.11; ENST00000505427.1; ENST00000508780.5; ENST00000512469.2; ENST00000379979.8
External Link	RMBase: m6A_site_677409
mod ID: M6ASITE069690		Click to Show/Hide the Full List
mod site	chr5:95822642-95822643:-		[9]
Sequence	CATGGCTCAAGAGTTTGTGAACTGCAAAATCCAGCCTGGGA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; A549; hESCs; fibroblasts; LCLs; Jurkat; CD4T; HEK293A-TOA; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000508780.5; ENST00000512469.2; ENST00000379979.8; ENST00000505427.1; ENST00000237858.11
External Link	RMBase: m6A_site_677410
mod ID: M6ASITE069691		Click to Show/Hide the Full List
mod site	chr5:95822677-95822678:-		[9]
Sequence	TGAGGATTCTTCCCGGGGAGACCGCAGCCCATCGGCATGGC
Motif Score	2.876744048
Cell/Tissue List	HEK293T; HeLa; A549; HepG2; H1B; hESCs; fibroblasts; LCLs; Jurkat; CD4T; HEK293A-TOA; MSC; TIME; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000379979.8; ENST00000237858.11; ENST00000508780.5; ENST00000505427.1; ENST00000512469.2
External Link	RMBase: m6A_site_677411

Ref 1	Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. doi: 10.1074/jbc.M110.119867. Epub 2010 May 12.
Ref 2	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 3	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 4	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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