m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01509)
Target Name E3 ubiquitin-protein ligase RNF5 (RNF5)
Synonyms
EC 2.3.2.27; RING finger protein 5; Ram1 homolog; HsRma1
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Gene Name RNF5
Chromosomal Location 6p21.32
Family RNF5 family
Function
Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).
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Gene ID 6048
Uniprot ID
RNF5_HUMAN
HGNC ID
HGNC:10068
KEGG ID
hsa:6048
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01509)
E3 ubiquitin-protein ligase RNF5 (RNF5)
N6-methyladenosine (m6A)
In total 8 m6A sequence/site(s) in this target gene
mod ID: M6ASITE074530 Click to Show/Hide the Full List
mod site chr6:32178499-32178500:+ [2]
Sequence TGAAGGGTACGTGGGGCGAAACAAAACCGGCCATGGCAGCA
Motif Score 2.20572619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000487940.1; ENST00000375094.4
External Link RMBase: m6A_site_712601
mod ID: M6ASITE074531 Click to Show/Hide the Full List
mod site chr6:32180449-32180450:+ [2]
Sequence TTGGCTAAGGCCAGCCCTGGACATTGTCCAGGAAGGCCTGG
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000375094.4
External Link RMBase: m6A_site_712602
mod ID: M6ASITE074532 Click to Show/Hide the Full List
mod site chr6:32180655-32180656:+ [3]
Sequence GGTGGGCAAAGTTCCCTCTGACTCTTCCCCCACTCCCCATC
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000375094.4
External Link RMBase: m6A_site_712603
mod ID: M6ASITE074533 Click to Show/Hide the Full List
mod site chr6:32180765-32180766:+ [2]
Sequence CCCTCACTACCTCCTTTAATACAAATTCAATAAAAAAGGTG
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000375094.4
External Link RMBase: m6A_site_712604
mod ID: M6ASITE094284 Click to Show/Hide the Full List
mod site GL000251.2:3618122-3618123:+ [4]
Sequence CCCAGGATCCCAGGTGAGAGACTGGAGGTGTTGCTTAGGGA
Motif Score 3.319380952
Cell/Tissue List HeLa; HEC-1-A
Seq Type List m6A-seq
Transcript ID List ENST00000488204.1; ENST00000456167.2
External Link RMBase: m6A_site_879652
mod ID: M6ASITE094285 Click to Show/Hide the Full List
mod site GL000251.2:3618235-3618236:+ [4]
Sequence TCCACTTCCTCAGATTAAAAACTCCACCCCGCCCCCAGGGC
Motif Score 2.627720238
Cell/Tissue List HeLa; HEC-1-A
Seq Type List m6A-seq
Transcript ID List ENST00000456167.2
External Link RMBase: m6A_site_879653
mod ID: M6ASITE094286 Click to Show/Hide the Full List
mod site GL000251.2:3618261-3618262:+ [4]
Sequence CCCCGCCCCCAGGGCCAGAGACCAGCTCCAGAGAGCAGAGG
Motif Score 2.876744048
Cell/Tissue List HeLa; HEC-1-A
Seq Type List m6A-seq
Transcript ID List ENST00000456167.2
External Link RMBase: m6A_site_879654
mod ID: M6ASITE094287 Click to Show/Hide the Full List
mod site GL000251.2:3618593-3618594:+ [4]
Sequence CCCACAGGTGTGGATCTGGGACAGGGTCACCCGGCCTCCAG
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000456167.2
External Link RMBase: m6A_site_879655
2'-O-Methylation (2'-O-Me)
In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000403 Click to Show/Hide the Full List
mod site chr6:32180657-32180658:+ [5]
Sequence TGGGCAAAGTTCCCTCTGACTCTTCCCCCACTCCCCATCTT
Cell/Tissue List HeLa
Seq Type List Nm-seq
Transcript ID List ENST00000375094.4
External Link RMBase: Nm_site_5812
mod ID: 2OMSITE000404 Click to Show/Hide the Full List
mod site chr6:32180659-32180660:+ [5]
Sequence GGCAAAGTTCCCTCTGACTCTTCCCCCACTCCCCATCTTAC
Cell/Tissue List HeLa
Seq Type List Nm-seq
Transcript ID List ENST00000375094.4
External Link RMBase: Nm_site_5813