m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01490)

Target Name	Hyaluronan synthase 2 (HAS2)
Synonyms	EC 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2 Click to Show/Hide
Gene Name	HAS2
Chromosomal Location	8q24.13
Family	NodC/HAS family
Function	Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (PubMed:20507985, PubMed:32993960, PubMed:23303191, PubMed:21228273) (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:8798477, PubMed:21228273, PubMed:20507985). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity). Click to Show/Hide
Gene ID	3037
Uniprot ID	HYAS2_HUMAN
HGNC ID	HGNC:4819
KEGG ID	hsa:3037

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01490)

Hyaluronan synthase 2 (HAS2)

N6-methyladenosine (m6A)

In total 38 m6A sequence/site(s) in this target gene
mod ID: M6ASITE086581		Click to Show/Hide the Full List
mod site	chr8:121613727-121613728:-		[2]
Sequence	CTATACAACCTAACTTATGGACTGTTTTGATAGATGATAAT
Motif Score	4.065041667
Cell/Tissue List	HEK293T; fibroblasts; A549; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807798
mod ID: M6ASITE086582		Click to Show/Hide the Full List
mod site	chr8:121613770-121613771:-		[2]
Sequence	GGAAGAAAAGGATTTTGGAAACTCAAGGAAAAGTTCTTTCA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807799
mod ID: M6ASITE086583		Click to Show/Hide the Full List
mod site	chr8:121613923-121613924:-		[3]
Sequence	CAATACATCAACAAGAAGAAACTCAGATTTAACCTGTTATT
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807800
mod ID: M6ASITE086584		Click to Show/Hide the Full List
mod site	chr8:121613944-121613945:-		[3]
Sequence	TTTCATTCTGCCAAAGTAAAACAATACATCAACAAGAAGAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807801
mod ID: M6ASITE086585		Click to Show/Hide the Full List
mod site	chr8:121613982-121613983:-		[3]
Sequence	CTGCTGGGACTTGAACAAAGACATTTATATGGGTTTATTTT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807802
mod ID: M6ASITE086586		Click to Show/Hide the Full List
mod site	chr8:121613988-121613989:-		[3]
Sequence	TCACTGCTGCTGGGACTTGAACAAAGACATTTATATGGGTT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807803
mod ID: M6ASITE086587		Click to Show/Hide the Full List
mod site	chr8:121613994-121613995:-		[3]
Sequence	GACATATCACTGCTGCTGGGACTTGAACAAAGACATTTATA
Motif Score	4.065041667
Cell/Tissue List	HEK293T; A549; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807804
mod ID: M6ASITE086588		Click to Show/Hide the Full List
mod site	chr8:121614013-121614014:-		[3]
Sequence	AGATAATGCCACCAAAGGAGACATATCACTGCTGCTGGGAC
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807805
mod ID: M6ASITE086589		Click to Show/Hide the Full List
mod site	chr8:121614138-121614139:-		[3]
Sequence	TGTGGCAGGCGGAAGAAGGGACAACAATATGACATGGTGCT
Motif Score	3.643047619
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807806
mod ID: M6ASITE086590		Click to Show/Hide the Full List
mod site	chr8:121614243-121614244:-		[4]
Sequence	AGGCCATTTTCAGAATCCAAACAGACAGTTCTAATTGTTGG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; H1B; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807807
mod ID: M6ASITE086591		Click to Show/Hide the Full List
mod site	chr8:121614336-121614337:-		[5]
Sequence	ATTGTTGTTAATTTCATAGGACTCATTCCAGTATCAGTTTG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807808
mod ID: M6ASITE086592		Click to Show/Hide the Full List
mod site	chr8:121614359-121614360:-		[5]
Sequence	GGGGCACATCAGGAAGGAAAACCATTGTTGTTAATTTCATA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807809
mod ID: M6ASITE086593		Click to Show/Hide the Full List
mod site	chr8:121614391-121614392:-		[5]
Sequence	GTTTGCAATTGCAACAATAAACAAAGCTGGGTGGGGCACAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807810
mod ID: M6ASITE086594		Click to Show/Hide the Full List
mod site	chr8:121614553-121614554:-		[2]
Sequence	CTACCGGGGTAAAATTTGGAACATTCTCCTCTTCTTGTTAA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807811
mod ID: M6ASITE086595		Click to Show/Hide the Full List
mod site	chr8:121614654-121614655:-		[5]
Sequence	AATGCAATGTGGTTTCACAAACATCACTTGTGGATGACCTA
Motif Score	2.20572619
Cell/Tissue List	U2OS; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807812
mod ID: M6ASITE086596		Click to Show/Hide the Full List
mod site	chr8:121614713-121614714:-		[5]
Sequence	TCAGATGGCTAAACCAGCAGACCCGTTGGAGCAAGTCCTAC
Motif Score	2.876744048
Cell/Tissue List	U2OS; fibroblasts; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807813
mod ID: M6ASITE086597		Click to Show/Hide the Full List
mod site	chr8:121614721-121614722:-		[5]
Sequence	AGAATATCTCAGATGGCTAAACCAGCAGACCCGTTGGAGCA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; U2OS; fibroblasts; A549; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807814
mod ID: M6ASITE086598		Click to Show/Hide the Full List
mod site	chr8:121614749-121614750:-		[3]
Sequence	GATCTAAGTGCCTTACTGAAACACCTATAGAATATCTCAGA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; U2OS; fibroblasts; MSC; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807815
mod ID: M6ASITE086599		Click to Show/Hide the Full List
mod site	chr8:121614811-121614812:-		[3]
Sequence	TGATGACAGGCATCTCACGAACCGGGTGCTGAGCCTGGGCT
Motif Score	2.930744048
Cell/Tissue List	HEK293T; A549; U2OS; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807816
mod ID: M6ASITE086600		Click to Show/Hide the Full List
mod site	chr8:121614901-121614902:-		[4]
Sequence	ACCTCTGGGAATGTACAGAAACTCCTTGTTGCATGAGTTTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; U2OS; hESCs; fibroblasts; A549; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807817
mod ID: M6ASITE086601		Click to Show/Hide the Full List
mod site	chr8:121614921-121614922:-		[2]
Sequence	TGTGTTCAGTGCATTAGTGGACCTCTGGGAATGTACAGAAA
Motif Score	3.622404762
Cell/Tissue List	HEK293T; hESCs; fibroblasts; A549; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807818
mod ID: M6ASITE086602		Click to Show/Hide the Full List
mod site	chr8:121628862-121628863:-		[3]
Sequence	ACGAAAAGGGTCCCGGTGAGACAGATGAGTCACATAAAGAA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807819
mod ID: M6ASITE086603		Click to Show/Hide the Full List
mod site	chr8:121628891-121628892:-		[3]
Sequence	AGCCACTTATATCTGGAAGAACAACTTCCACGAAAAGGGTC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807820
mod ID: M6ASITE086604		Click to Show/Hide the Full List
mod site	chr8:121628918-121628919:-		[3]
Sequence	CAGTGAAGTCATGGGCAGAGACAAATCAGCCACTTATATCT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; U2OS; H1B; hNPCs; hESCs; fibroblasts; GSC-11; iSLK; MSC
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807821
mod ID: M6ASITE086605		Click to Show/Hide the Full List
mod site	chr8:121628945-121628946:-		[3]
Sequence	AGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGG
Motif Score	3.643047619
Cell/Tissue List	HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GSC-11; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807822
mod ID: M6ASITE086606		Click to Show/Hide the Full List
mod site	chr8:121628972-121628973:-		[3]
Sequence	TGTCATGGTCATAGATGGGAACTCAGAAGATGACCTTTACA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807823
mod ID: M6ASITE086607		Click to Show/Hide the Full List
mod site	chr8:121629050-121629051:-		[3]
Sequence	TGCCTATCAAGAAGATCCAGACTACTTAAGGAAATGTTTGC
Motif Score	3.319380952
Cell/Tissue List	HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807824
mod ID: M6ASITE086608		Click to Show/Hide the Full List
mod site	chr8:121629090-121629091:-		[4]
Sequence	CCCCCATAAAGTTGAACAAAACAGTTGCCCTTTGCATCGCT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; U2OS; hESCs; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807825
mod ID: M6ASITE086609		Click to Show/Hide the Full List
mod site	chr8:121629095-121629096:-		[4]
Sequence	AGAAACCCCCATAAAGTTGAACAAAACAGTTGCCCTTTGCA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; U2OS; hESCs; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807826
mod ID: M6ASITE086610		Click to Show/Hide the Full List
mod site	chr8:121629111-121629112:-		[4]
Sequence	AAATGAAAAAATCCCTAGAAACCCCCATAAAGTTGAACAAA
Motif Score	2.185083333
Cell/Tissue List	HEK293T; U2OS; hESCs; fibroblasts; A549; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807827
mod ID: M6ASITE086611		Click to Show/Hide the Full List
mod site	chr8:121629175-121629176:-		[6]
Sequence	TATGGTGCCTTTTTGGCATCACACCTCATCATCCAAAGCCT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807828
mod ID: M6ASITE086612		Click to Show/Hide the Full List
mod site	chr8:121629199-121629200:-		[7]
Sequence	AATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTGGC
Motif Score	4.065041667
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807829
mod ID: M6ASITE086613		Click to Show/Hide the Full List
mod site	chr8:121641189-121641190:-		[8]
Sequence	CTGTTATCGGGGGCAGAAAGACTGAAGCCCAAAAAAAAAAA
Motif Score	3.319380952
Cell/Tissue List	H1B; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807831
mod ID: M6ASITE086614		Click to Show/Hide the Full List
mod site	chr8:121641304-121641305:-		[3]
Sequence	TGAAACAGCCCCAGCCAAAGACTTTTCTCCCAATTCTGCGC
Motif Score	3.319380952
Cell/Tissue List	A549; H1A; H1B; fibroblasts; GSC-11; iSLK; MSC; GSCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807834
mod ID: M6ASITE086615		Click to Show/Hide the Full List
mod site	chr8:121641320-121641321:-		[3]
Sequence	CATTGAACCAGAGACTTGAAACAGCCCCAGCCAAAGACTTT
Motif Score	2.20572619
Cell/Tissue List	A549; H1A; H1B; fibroblasts; GSC-11; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807835
mod ID: M6ASITE086616		Click to Show/Hide the Full List
mod site	chr8:121641327-121641328:-		[3]
Sequence	AGCAGCCCATTGAACCAGAGACTTGAAACAGCCCCAGCCAA
Motif Score	3.319380952
Cell/Tissue List	A549; H1A; H1B; fibroblasts; GSC-11; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807836
mod ID: M6ASITE086617		Click to Show/Hide the Full List
mod site	chr8:121641334-121641335:-		[3]
Sequence	GGCTTCGAGCAGCCCATTGAACCAGAGACTTGAAACAGCCC
Motif Score	2.930744048
Cell/Tissue List	A549; H1A; H1B; fibroblasts; GSC-11; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807837
mod ID: M6ASITE086618		Click to Show/Hide the Full List
mod site	chr8:121641437-121641438:-		[3]
Sequence	CCACCAGCTCACTTGTTAAGACCCCCTTAAGTTGGAGGAGG
Motif Score	2.876744048
Cell/Tissue List	A549; H1B; fibroblasts; GSC-11; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000303924.5
External Link	RMBase: m6A_site_807839

Ref 1	Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20. doi: 10.1517/17425250902970998.
Ref 2	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 3	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 4	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 5	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 8	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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