General Information of the m6A Target Gene (ID: M6ATAR01472)
Target Name Diacylglycerol kinase eta (DGKH)
Synonyms
DAG kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta
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Gene Name Dgkh
Chromosomal Location 13q14.11
Family Eukaryotic diacylglycerol kinase family
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016).
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Gene ID 160851
Uniprot ID
DGKH_HUMAN
HGNC ID
HGNC:2854
KEGG ID
hsa:160851
References
Ref 1 US patent application no. 6,426,221, Antisense modulation of RIP2 expression.